表孕烷醇酮

表孕烷醇酮
	IUPAC名; 3β-Hydoxy-5β-pregnan-20-one
	系统名; 1-[(1S,2S,5S,7R,10R,11S,14S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-14-yl]ethanone; 1-[(1S,2S,5S,7R,10R,11S,14S,15S)-2,15-二甲基-5-羟基四环[8.7.0.02,7.011,15]-14-十七烷基]乙酮
别名	3β,5β-Tetrahydroprogesterone
识别
CAS号	128-21-2
PubChem	228491
ChemSpider	198867
SMILES	CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@@H](C4)O)C)C;
性质
化学式	C21H34O2
摩尔质量	318.49 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

表孕烷醇酮（英語：Epipregnanolone，暨3β-羟基-5β-孕烷-20-酮，3β-hydroxy-5β-pregnan-20-one，也被称为3β,5β-四氢孕酮，3β,5β-tetrahydroprogesterone，3β,5β-THP）是一种内源性神经甾体^[1]，是GABA_A受体的负向别构调节剂，可逆转别孕烷醇酮等正向别构调节剂的作用^[2]^[3]。

表孕烷醇酮本身并不是孕激素，但可以代谢为其它孕烷衍生物而有孕激素功能^[4]。

另见编辑

参考文献编辑

^ Neurosteroids and Brain Function. Academic Press. 12 December 2001: 18–. ISBN 978-0-08-054423-6.
^ Abraham Weizman. Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment. Springer Science & Business Media. 1 February 2008: 6–. ISBN 978-1-4020-6854-6.
^ Jan Egebjerg; Arne Schousboe; Povl Krogsgaard-Larsen. Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology. CRC Press. 4 October 2001: 248–. ISBN 978-0-7484-0881-8.
^ Beyer, C.; González-Flores, O.; Ramı́rez-Orduña, J.M.; González-Mariscal, G. Indomethacin Inhibits Lordosis Induced by Ring A-Reduced Progestins: Possible Role of 3α-Oxoreduction in Progestin-Facilitated Lordosis. Hormones and Behavior. 1999, 35 (1): 1–8. ISSN 0018-506X. doi:10.1006/hbeh.1998.1457.

[1] Neurosteroids and Brain Function. Academic Press. 12 December 2001: 18–. ISBN 978-0-08-054423-6.

[Weizman2008-2] Abraham Weizman. Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment. Springer Science & Business Media. 1 February 2008: 6–. ISBN 978-1-4020-6854-6.

[EgebjergSchousboe2001-3] Jan Egebjerg; Arne Schousboe; Povl Krogsgaard-Larsen. Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology. CRC Press. 4 October 2001: 248–. ISBN 978-0-7484-0881-8.

[BeyerGonzález-Flores1999-4] Beyer, C.; González-Flores, O.; Ramı́rez-Orduña, J.M.; González-Mariscal, G. Indomethacin Inhibits Lordosis Induced by Ring A-Reduced Progestins: Possible Role of 3α-Oxoreduction in Progestin-Facilitated Lordosis. Hormones and Behavior. 1999, 35 (1): 1–8. ISSN 0018-506X. doi:10.1006/hbeh.1998.1457.

[1]

[2]

[3]

[4]

表孕烷醇酮

IUPAC名 3β-Hydoxy-5β-pregnan-20-one
系统名 1-[(1S,2S,5S,7R,10R,11S,14S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^2,7.0^11,15]heptadec-14-yl]ethanone 1-[(1S,2S,5S,7R,10R,11S,14S,15S)-2,15-二甲基-5-羟基四环[8.7.0.0^2,7.0^11,15]-14-十七烷基]乙酮
别名	3β,5β-Tetrahydroprogesterone
识别
CAS号	128-21-2
PubChem	228491
ChemSpider	198867
SMILES	CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@@H](C4)O)C)C
性质
化学式	C₂₁H₃₄O₂
摩尔质量	318.49 g·mol⁻¹
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

表孕烷醇酮

另见 编辑

参考文献 编辑

另见编辑

参考文献编辑