轉錄泡泡(Transcription bubble)是在DNA轉錄過程中,當DNA雙鏈的局部解旋時所形成的分子結構。轉錄泡泡的大小範圍為12-14個鹼基對。當RNA聚合酶啟動子結合並導致兩條DNA鏈分離時,就會形成轉錄泡泡。[1]它顯示了一個未配對的DNA區域,在雙螺旋的每條鏈上都暴露出一小段核苷酸[1][2]

A molecular structure composed of unwound and unpaired DNA, where a short stretch of nucleotides are exposed on each strand of the double helix, allowing RNA polymerase binding, and nascent RNA synthesis within this region.

RNA聚合酶 编辑

參見 编辑

參考資料 编辑

  1. ^ 1.0 1.1 Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Morgan, David; Raff, Martin; Roberts, Keith; Walter, Peter. Wilson, John; Hunt, Tim , 编. Molecular Biology of the Cell 6. Garland Science. 2015: 306–307. ISBN 9781315735368. doi:10.1201/9781315735368 (英语). 
  2. ^ Clark, David P.; Pazdernik, Nanette J., Clark, David P.; Pazdernik, Nanette J. , 编, Chapter 2 - DNA, RNA, and Protein, Biotechnology (Second Edition) (Academic Cell), 2016-01-01: 33–61 [2019-09-30], ISBN 9780123850157, doi:10.1016/b978-0-12-385015-7.00002-8, (原始内容存档于2023-02-13)