4-(4-甲基-1-哌嗪基)苯胺
化合物
4-(4-甲基-1-哌嗪基)苯胺是一种有机化合物，化学式为C11H17N3。它可由1-甲基-4-(4-硝基苯基)哌嗪的还原反应制得，[2]或由4-溴苯胺和N-甲基哌嗪在磷酸钾的存在下反应得到。[3]它和氯乙酰氯反应，可以得到N-氯乙酰基-4-(4-甲基-1-哌嗪基)苯胺。[4]
| 4-(4-甲基-1-哌嗪基)苯胺 | |
|---|---|
aniline.svg)
| |
| 别名 | 4-(4-甲基哌嗪基)苯胺 4-甲基-1-(4-氨基苯基)哌嗪 |
| 识别 | |
| CAS号 | 16153-81-4 
|
| 性质 | |
| 化学式 | C11H17N3 |
| 摩尔质量 | 191.27 g·mol−1 |
| 熔点 | 93 °C（366 K）[1] |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
参考文献 编辑
- ^ Loewe, Heinz; Mieth, H.; Urbanietz, Josef. 4-Aminoquinoline. Arzneimittel-Forschung, 1966. 16 (10): 1306-1310. ISSN 0004-4172.
- ^ Yuan-Yuan Hei, Ying Shen, Jin Wang, Hao Zhang, Hong-Yi Zhao, Minhang Xin, Yong-Xiao Cao, Yan Li, San-Qi Zhang. Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors. Bioorganic & Medicinal Chemistry. 2018-05, 26 (8): 2173–2185 [2021-10-11]. doi:10.1016/j.bmc.2018.03.025 （英语）.
- ^ Subhajit Bhunia, S. Vijay Kumar, Dawei Ma. N , N ′-Bisoxalamides Enhance the Catalytic Activity in Cu-Catalyzed Coupling of (Hetero)Aryl Bromides with Anilines and Secondary Amines. The Journal of Organic Chemistry. 2017-12-01, 82 (23): 12603–12612 [2021-10-11]. ISSN 0022-3263. doi:10.1021/acs.joc.7b02363. （原始内容存档于2021-12-15） （英语）.
- ^ Huan Liu, Yi Li, Xiang-Ying Wang, Bo Wang, Hai-Yun He, Ji-Yan Liu, Ming-Li Xiang, Jun He, Xiao-Hua Wu, Li Yang. Synthesis, preliminary structure–activity relationships, and in vitro biological evaluation of 6-aryl-3-amino-thieno[2,3-b]pyridine derivatives as potential anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters. 2013-04, 23 (8): 2349–2352 [2021-10-11]. doi:10.1016/j.bmcl.2013.02.059. （原始内容存档于2021-10-20） （英语）.