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摘要

描述
English: "Genetic correlation results of the multivariate GenLang GWAS analysis with comparisons with those for the largest published GWAS of full-scale IQ in LD Hub. Summary statistics for full-scale IQ (n = 257,828) were obtained from the Social Science Genetic Association Consortium (18). Genetic correlations between the multivariate GenLang results (blue–green), full-scale IQ (purple), and traits in LD Hub reveal an overlap with cognitive traits, education, eyesight, chronotype, lifestyle, well-being, psychiatric disorders, pain, physical health and exercise, and socioeconomic status. A subset of representative traits is shown; 143 traits showed significant associations with the multivariate GenLang results, and 245 traits showed significant correlations with full-scale IQ, of which 135 traits overlap after correction for multiple testing for 535 × 2 traits (P < 4.67 × 10−5). Significant correlations are shown in dark colors; nonsignificant correlations are in light colors. Full results can be found in Dataset S13. UKBB: UK Biobank, GCSE: General Certificate of Secondary Education, NVQ: National Vocational Qualification, HND: Higher National Diploma, HNC: Higher National Certificate, CSE: Certificate of Secondary Education, PGC: Psychiatric Genomics Consortium, BMI: body mass index, SES: socioeconomic status. Genetic correlation (rg) is presented as a dot, and error bars indicate the SE."
日期
来源 https://www.pnas.org/doi/full/10.1073/pnas.2202764119
作者

Authors of the study:

Else Eising https://orcid.org/0000-0001-9819-1260, Nazanin Mirza-Schreiber, Eveline L. de Zeeuw, Carol A. Wang, Dongnhu T. Truong, Andrea G. Allegrini, Chin Yang Shapland https://orcid.org/0000-0002-5797-1241, Gu Zhu, Karen G. Wigg, Margot L. Gerritse, Barbara Molz https://orcid.org/0000-0002-9300-761X, Gökberk Alagöz https://orcid.org/0000-0003-0530-2780, Alessandro Gialluisi https://orcid.org/0000-0002-7388-4463, Filippo Abbondanza, Kaili Rimfeld https://orcid.org/0000-0001-5139-065X, Marjolein van Donkelaar, Zhijie Liao https://orcid.org/0000-0003-2351-0022, Philip R. Jansen, Till F. M. Andlauer https://orcid.org/0000-0002-2917-5889, Timothy C. Bates https://orcid.org/0000-0002-1153-9007, Manon Bernard, Kirsten Blokland https://orcid.org/0000-0002-0080-8320, Milene Bonte, Anders D. Børglum, Thomas Bourgeron, Daniel Brandeis, Fabiola Ceroni https://orcid.org/0000-0002-7474-6361, Valéria Csépe, Philip S. Dale https://orcid.org/0000-0002-7697-8510, Peter F. de Jong https://orcid.org/0000-0002-8806-0563, John C. DeFries, Jean-François Démonet, Ditte Demontis https://orcid.org/0000-0001-9124-2766, Yu Feng, Scott D. Gordon, Sharon L. Guger, Marianna E. Hayiou-Thomas https://orcid.org/0000-0003-1163-2671, Juan A. Hernández-Cabrera, Jouke-Jan Hottenga, Charles Hulme https://orcid.org/0000-0001-9499-5958, Juha Kere, Elizabeth N. Kerr https://orcid.org/0000-0002-9589-6502, Tanner Koomar, Karin Landerl, Gabriel T. Leonard, Maureen W. Lovett, Heikki Lyytinen, Nicholas G. Martin, Angela Martinelli, Urs Maurer, Jacob J. Michaelson, Kristina Moll, Anthony P. Monaco https://orcid.org/0000-0001-7480-3197, Angela T. Morgan https://orcid.org/0000-0003-1147-7405, Markus M. Nöthen https://orcid.org/0000-0002-8770-2464, Zdenka Pausova, Craig E. Pennell, Bruce F. Pennington https://orcid.org/0000-0001-9541-8204, Kaitlyn M. Price, Veera M. Rajagopal https://orcid.org/0000-0002-5236-168X, Franck Ramus, Louis Richer https://orcid.org/0000-0002-6590-3046, Nuala H. Simpson, Shelley D. Smith, Margaret J. Snowling https://orcid.org/0000-0003-0836-3861, John Stein https://orcid.org/0000-0001-5843-8986, Lisa J. Strug https://orcid.org/0000-0003-0503-9740, Joel B. Talcott, Henning Tiemeier, Marc P. van der Schroeff https://orcid.org/0000-0002-1360-8782, Ellen Verhoef https://orcid.org/0000-0002-8315-1095, Kate E. Watkins https://orcid.org/0000-0002-2621-482X, Margaret Wilkinson https://orcid.org/0000-0001-5735-4051, Margaret J. Wright, Cathy L. Barr https://orcid.org/0000-0003-0361-0106, Dorret I. Boomsma https://orcid.org/0000-0002-7099-7972, Manuel Carreiras https://orcid.org/0000-0001-6726-7613, Marie-Christine J. Franken, Jeffrey R. Gruen https://orcid.org/0000-0001-7640-2071, Michelle Luciano https://orcid.org/0000-0002-7306-3008, Bertram Müller-Myhsok https://orcid.org/0000-0002-0719-101X, Dianne F. Newbury, Richard K. Olson, Silvia Paracchini, Tomáš Paus, Robert Plomin, Sheena Reilly https://orcid.org/0000-0001-6506-4767, Gerd Schulte-Körne, J. Bruce Tomblin, Elsje van Bergen, Andrew J. O. Whitehouse, Erik G. Willcutt, Beate St Pourcain, Clyde Francks https://orcid.org/0000-0002-9098-890X, and Simon E. Fisher https://orcid.org/0000-0002-3132-1996 (and edited by Uta Frith)

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From the study "Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people"

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当前2022年9月22日 (四) 10:402022年9月22日 (四) 10:40版本的缩略图2,920 × 3,875（1.22 MB）PrototyperspectiveUploaded a work by Authors of the study: Else Eising https://orcid.org/0000-0001-9819-1260, Nazanin Mirza-Schreiber, Eveline L. de Zeeuw, Carol A. Wang, Dongnhu T. Truong, Andrea G. Allegrini, Chin Yang Shapland https://orcid.org/0000-0002-5797-1241, Gu Zhu, Karen G. Wigg, Margot L. Gerritse, Barbara Molz https://orcid.org/0000-0002-9300-761X, Gökberk Alagöz https://orcid.org/0000-0003-0530-2780, Alessandro Gialluisi https://orcid.org/0000-0002-7388-4463, Filippo Abbondanza, Kaili Rimfeld htt...

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