主要碱性蛋白

主要碱性蛋白(英語:Major basic protein,MBP),全称为嗜酸性粒细胞主要碱性蛋白(英語:Eosinophil Major basic protein),也称为蛋白多糖2(Proteoglycan 2,PRG2),是一种由人类基因PRG2编码的蛋白质[5]

主要碱性蛋白
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名PRG2;, BMPG, MBP, MBP1, proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein), proMBP, proteoglycan 2, pro eosinophil major basic protein
外部IDOMIM605601 MGI103294 HomoloGene2044 GeneCardsPRG2
基因位置(人类
11號染色體
染色体11號染色體[1]
11號染色體
主要碱性蛋白的基因位置
主要碱性蛋白的基因位置
基因座11q12.1起始57,386,780 bp[1]
终止57,390,650 bp[1]
RNA表达模式
PBB GE PRG2 211743 s at fs.png
查阅更多表达数据
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_002728
NM_001243245
NM_001302926
NM_001302927

NM_008920

蛋白序列

NP_001230174
NP_001289855
NP_001289856
NP_002719

NP_032946

基因位置​(UCSC)Chr 11: 57.39 – 57.39 MbChr 2: 84.98 – 84.98 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

MBP在结构上类似于凝集素(糖结合蛋白),特别是与C-型凝集素在折叠上相似。但与C-型凝集素不同(C-型凝集素在的存在下会结合各种碳水化合物),MBP既不与钙结合也不与这些糖类结合,而是识别並結合硫酸乙酰肝素(heparan sulfate)。MBP的两种晶体结构已被测定。[6][7]

相互作用编辑

主要碱性蛋白已知可与妊娠相关血浆蛋白A发生蛋白質交互作用[8][9][10]

参考文献编辑

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000186652 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000027073 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Entrez Gene: PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein). (原始内容存档于2008-11-02). 
  6. ^ PDB 1h8u; Swaminathan GJ, Weaver AJ, Loegering DA, Checkel JL, Leonidas DD, Gleich GJ, Acharya KR. Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificity. J. Biol. Chem. July 2001, 276 (28): 26197–26203. PMID 11319227. doi:10.1074/jbc.M100848200. 
  7. ^ PDB 2brs; Swaminathan GJ, Myszka DG, Katsamba PS, Ohnuki LE, Gleich GJ, Acharya KR. Eosinophil-granule major basic protein, a C-type lectin, binds heparin. Biochemistry. November 2005, 44 (43): 14152–14158. PMID 16245931. doi:10.1021/bi051112b. 
  8. ^ Overgaard, M T; Haaning J; Boldt H B; Olsen I M; Laursen L S; Christiansen M; Gleich G J; Sottrup-Jensen L; Conover C A; Oxvig C. Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor. J. Biol. Chem. (UNITED STATES). October 2000, 275 (40): 31128–31133. ISSN 0021-9258. PMID 10913121. doi:10.1074/jbc.M001384200. 
  9. ^ Overgaard MT, Sorensen ES, Stachowiak D, Boldt HB, Kristensen L, Sottrup-Jensen L, Oxvig C. Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment. J. Biol. Chem. (United States). January 2003, 278 (4): 2106–2117. ISSN 0021-9258. PMID 12421832. doi:10.1074/jbc.M208777200. 
  10. ^ Oxvig, C; Sand O; Kristensen T; Gleich G J; Sottrup-Jensen L. Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein. J. Biol. Chem. (UNITED STATES). June 1993, 268 (17): 12243–6. ISSN 0021-9258. PMID 7685339. 

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