催产素酶

催产素酶Oxytocinase)是一種可以代謝催产素[1]。最著名的催产素酶是Leucyl-cystinyl氨肽酶英语leucyl/cystinyl aminopeptidase[1][2],本身也是腦啡肽酶,已知也有其他的催产素酶[1][3]

抑制劑编辑

阿嗎他定英语Amastatin短整合蛋白英语lebestatin(ubenimex)及嘌呤霉素英语puromycin都可以抑制催产素的代謝,不過他們也會抑制其他多肽(像是後葉加壓素甲硫腦素英语met-enkephalin強啡肽英语dynorphin A等)的分解,[4][3][5]EDTA、L-甲硫氨酸邻二氮菲磷酸阿米酮英语phosphoramidon也會抑制催产素的代謝[6]

相關條目编辑

參考資料编辑

  1. ^ 1.0 1.1 1.2 Tsujimoto M, Hattori A. The oxytocinase subfamily of M1 aminopeptidases. Biochim. Biophys. Acta. 2005, 1751 (1): 9–18. PMID 16054015. doi:10.1016/j.bbapap.2004.09.011. 
  2. ^ Nomura S, Ito T, Yamamoto E, Sumigama S, Iwase A, Okada M, Shibata K, Ando H, Ino K, Kikkawa F, Mizutani S. Gene regulation and physiological function of placental leucine aminopeptidase/oxytocinase during pregnancy. Biochim. Biophys. Acta. 2005, 1751 (1): 19–25. PMID 15894523. doi:10.1016/j.bbapap.2005.04.006. 
  3. ^ 3.0 3.1 Mizutani S, Yokosawa H, Tomoda Y. Degradation of oxytocin by the human placenta: effect of selective inhibitors. Acta Endocrinol. 1992, 127 (1): 76–80. PMID 1355623. doi:10.1530/acta.0.1270076. 
  4. ^ Meisenberg G, Simmons WH. Amastatin potentiates the behavioral effects of vasopressin and oxytocin in mice. Peptides. 1984, 5 (3): 535–9. PMID 6540873. doi:10.1016/0196-9781(84)90083-4. 
  5. ^ Stancampiano R, Melis MR, Argiolas A. Proteolytic conversion of oxytocin by brain synaptic membranes: role of aminopeptidases and endopeptidases. Peptides. 1991, 12 (5): 1119–25. PMID 1800950. doi:10.1016/0196-9781(91)90068-z. 
  6. ^ Itoh C, Watanabe M, Nagamatsu A, Soeda S, Kawarabayashi T, Shimeno H. Two molecular species of oxytocinase (L-cystine aminopeptidase) in human placenta: purification and characterization. Biol. Pharm. Bull. 1997, 20 (1): 20–4. PMID 9013800. doi:10.1248/bpb.20.20.