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抗高血壓藥(英文:Anti-hypertensives

作用机理编辑

  • 利尿劑:透過排除體內鈉離子與降低血液體積或其他機制來降低血壓
  • 交感神經抑制劑:降低周邊血管阻力、抑制心臟功能、增加容量血管中的靜脈血鬱積(後兩者會降低心輸出)
  • 直接血管舒張劑:使血管平滑肌放鬆,因此降低血管阻力與增加容量
  • 阻斷血管收縮素的作用與產生

代表药物编辑

参见编辑

參考文獻编辑

  • Chobanian AV et al.(2003)"The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report." JAMA. 289,2560-72. PMID 12748199
  • ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group(2002)"Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)." JAMA. 288,2981-97. PMID 12479763
  • Bangalore S, Kamalakkannan G, Parkar S and Messerli FH.(2007)"Fixed-dose combinations improve medication compliance: a meta-analysis."Am.J.Med. 120, 713-9. PMID 17679131