敌百虫

敌百虫(英語:trichlorfon,也称为美曲磷酯,Metrifonate)是一种有机磷酸酯杀虫剂乙酰胆碱酯酶抑制剂英语acetylcholinesterase inhibitor[3],是一种前体药物,可在非酶促情况下转化为敌敌畏, 可用于治疗血吸虫病[4],但没有商业化应用[5],也有提议用于治疗阿茲海默症,但并未通过[6]

敌百虫
Trichlorfon.PNG
系统(IUPAC)命名名称
(RS)-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate
临床数据
商品名Chlorophos (and many others)[1]Trichlorfon; Phosphonic acid, (2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl) dimethylphosphonate; Agroforotox; Anthon; Chlorofos; Chloroftalm; Chlorophos; Chlorophthalm; Chloroxyphos; Combot; Dimethyl (trichlorohydroxyethyl)phosphonate; Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate; Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate; Dipterax; Dipterex; Dipterex 50; Diptevur; Ditrifon; Dylox; Dyrex; Dyvon; DEP; DEP (Pesticide); DETF; ENT 19,763; Flibol E; Fliegenteller; Forotox; Foschlor; Foschlor R; Foschlor R 50; Hypodermacid; Loisol; Masoten; Mazoten; Methyl Chlorophos; Metifonate; Metriphonate; Neguron; Neguvon; O,O-Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate; O,O-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate; O,O-Dimethyl (2,2,2-trichlorohydroxyethyl)phosphonate; Phoschlor; Phoschlor R50; Polfoschlor; Ricifon; Ritsifon; Soldep; Sotipox; Trichlorphon; Trichlorphon FN; Tugon; Volfartol; Votexit; Wotexit; WEC 50; (1-Hydroxy-2,2,2-trichloroethyl)phosphonic acid, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl)phosphonate, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl)phosphonic acid dimethyl ester; Bayer L 1359; Bilarcil; Bovinox; Briton; BAY 15922; Cekufon; Chlorophosciclosom; Clorofos; Danex; Dimethoxy-(2,2,2-trichloro-1-hydroxyethyl)phosphine oxide; Equino-Aid; Foschlorem; Khloroftalm; NCI-C54831; O,O-Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphate; O,O-Dimethyl-(1-hydroxy-2,2,2-trichloraethyl)phosphosaeure ester; O,O-Dimethyl-(1-hydroxy-2,2,2-trichlorathyl)-phosphat; O,O-Dimethyl-(2,2,2-trichloor-1-hydroxy-ethyl)-fosfonaat; O,O-Dimethyl-(2,2,2-trichlor-1-hydroxy-aethyl)phosphonat; O,O-Dimetil-(2,2,2-tricloro-1-idrossi-etil)-fosfonato; Phosphonic acid, (1-hydroxy-2,2,2-trichloroethyl)-, dimethyl ester; Proxol; Trichloorfon; Trichlorofon; Trichlorophon; Trinex; 1-Hydroxy-2,2,2-trichloro-ethyle phosphonate de dimethyle; Bay-L 1359; Briten; Denkaphon; Dipterex WP 80; Ertefon; OMS 800; Zeltivar; Onefon; O,O-Dimethyl-1-oxy-2,2,2-trichloroethyl phosphonate;Trichlorfon; 1-Hydroxy-2,2,2-trichloroethylphosphonate-O,O-dimethyl ester; Phosphonic acid, P-(2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester; Chlorak; Dimetox; Dioxaphos[2]
Drugs.com国际药品名称
药代动力学数据
生物半衰期3 hours
识别信息
CAS注册号52-68-6  ✓
ATC代码P02BB01 QP52英语ATCvet code QP52AB01 QP53英语ATCvet code QP53AF02
PubChemCID 5853
ChemSpider5644 ☒N
UNIIDBF2DG4G2K ✓
KEGGC07971 ✓
ChEBICHEBI:6908 ☒N
其他名称Trichlorphon
化学信息
化学式C4H8Cl3O4P
摩尔质量257.436 g/mol
手性Racemic mixture

参考文献编辑

  1. ^ Trichlorfon. Haz-Map. U.S. National Library of Medicine. August 2015 [2015-10-13]. (原始内容存档于2015-09-20). 
  2. ^ Metrifonate. U.S. National Institute of Standards and Technology. [2016-09-04]. (原始内容存档于2020-04-03). 
  3. ^ NLH - Neurological Conditions - Metrifonate for Alzheimer's disease. (原始内容存档于2009-07-19). 
  4. ^ Monographs: Pharmaceutical substances: Metrifonate (Metrifonatum). The International Pharmacopoeia Fourth Edition. WHO. [2015-10-20]. (原始内容存档于2016-06-03).  (dead link 31 January 2019)
  5. ^ Ross AG, Bartley PB, Sleigh AC, Olds GR, Li Y, Williams GM, McManus DP. Schistosomiasis. The New England Journal of Medicine. April 2002, 346 (16): 1212–20. PMID 11961151. doi:10.1056/NEJMra012396. 
  6. ^ López-Arrieta JM, Schneider L. López-Arrieta J , 编. Metrifonate for Alzheimer's disease. The Cochrane Database of Systematic Reviews. April 2006, (2): CD003155. PMID 16625573. doi:10.1002/14651858.CD003155.pub3.