早幼粒细胞白血病蛋白

Promyelocytic leukemia; 早幼粒细胞白血病蛋白
	PDB rendering based on 1bor.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1BOR
标识
代号	PML; MYL; PP8675; RNF71; TRIM19
扩展标识	遗传学：102578 鼠基因：104662 同源基因：13245 GeneCards: PML Gene
基因本体论描述
分子功能	· DNA binding; · transcription coactivator activity; · protein binding; · zinc ion binding; · ubiquitin protein ligase binding; · SUMO binding; · protein homodimerization activity; · SMAD binding; · protein heterodimerization activity; · cobalt ion binding;
细胞成分	· nucleus; · nucleoplasm; · nucleolus; · cytoplasm; · cytosol; · nuclear matrix; · PML body; · early endosome membrane; · nuclear membrane; · extrinsic component of endoplasmic reticulum membrane;
生物过程	· response to hypoxia; · regulation of protein phosphorylation; · positive regulation of defense response to virus by host; · transcription, DNA-templated; · regulation of transcription, DNA-templated; · protein complex assembly; · protein targeting; · apoptotic process; · activation of cysteine-type endopeptidase activity involved in apoptotic process; · DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; · cell cycle arrest; · transforming growth factor beta receptor signaling pathway; · common-partner SMAD protein phosphorylation; · SMAD protein import into nucleus; · negative regulation of cell proliferation; · intrinsic apoptotic signaling pathway in response to DNA damage; · intrinsic apoptotic signaling pathway in response to oxidative stress; · response to UV; · response to gamma radiation; · regulation of calcium ion transport into cytosol; · viral process; · negative regulation of angiogenesis; · cytokine-mediated signaling pathway; · myeloid cell differentiation; · negative regulation of cell growth; · PML body organization; · positive regulation of histone deacetylation; · negative regulation of telomere maintenance via telomerase; · endoplasmic reticulum calcium ion homeostasis; · circadian regulation of gene expression; · negative regulation of translation in response to oxidative stress; · response to cytokine; · regulation of circadian rhythm; · intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; · entrainment of circadian clock by photoperiod; · proteasome-mediated ubiquitin-dependent protein catabolic process; · innate immune response; · cell fate commitment; · regulation of MHC class I biosynthetic process; · negative regulation of transcription, DNA-templated; · negative regulation of mitotic cell cycle; · retinoic acid receptor signaling pathway; · protein stabilization; · maintenance of protein location in nucleus; · defense response to virus; · negative regulation of telomerase activity; · positive regulation of apoptotic process involved in mammary gland involution; · interferon-gamma-mediated signaling pathway; · branching involved in mammary gland duct morphogenesis; · intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; · cellular response to interleukin-4; · cellular senescence; · extrinsic apoptotic signaling pathway; · negative regulation of viral release from host cell; · negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; · regulation of double-strand break repair; · positive regulation of extrinsic apoptotic signaling pathway;
	Sources: Amigo / QuickGO
直系同源体
	查; 论; 编;

早幼粒细胞白血病蛋白是指可能的转录因子可能的转录因子（英語：Probable transcription factor PML），是一个由人类基因 PML 编码的抑癌蛋白。

功能编辑

互作编辑

早幼粒细胞白血病蛋白可与下列蛋白質发生交互作用：

参见编辑

RING finger domain

参考文献编辑

^ Kojic, Snezana; Medeot, Elisa; Guccione, Ernesto; Krmac, Helena; Zara, Ivano; Martinelli, Valentina; Valle, Giorgio; Faulkner, Georgine. The Ankrd2 Protein, a Link Between the Sarcomere and the Nucleus in Skeletal Muscle. Journal of Molecular Biology. 2004-05, 339 (2) [2022-06-16]. doi:10.1016/j.jmb.2004.03.071. （原始内容存档于2022-06-15）（英语）.
^ ^2.0 ^2.1 Zhong, Sue; Delva, Laurent; Rachez, Christophe; Cenciarelli, Cristina; Gandini, Domenica; Zhang, Hui; Kalantry, Sundeep; Freedman, Leonard P.; Pandolfi, Pier Paolo. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARα and T18 oncoproteins. Nature Genetics. 1999-11, 23 (3) [2022-06-16]. ISSN 1061-4036. PMID 10610177. doi:10.1038/15463. （原始内容存档于2022-03-10）（英语）.
^ ^3.0 ^3.1 Matsuzaki, Kazuhito; Minami, Takeshi; Tojo, Masahide; Honda, Yoshiomi; Saitoh, Noriko; Nagahiro, Shinji; Saya, Hideyuki; Nakao, Mitsuyoshi. PML-nuclear bodies are involved in cellular serum response. Genes to Cells: Devoted to Molecular & Cellular Mechanisms. 2003-03, 8 (3) [2022-06-16]. ISSN 1356-9597. PMID 12622724. doi:10.1046/j.1365-2443.2003.00632.x. （原始内容存档于2022-06-16）.
^ Doucas, Vassilis; Tini, Marc; Egan, David A.; Evans, Ronald M. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. Proceedings of the National Academy of Sciences. 1999-03-16, 96 (6) [2022-06-16]. ISSN 0027-8424. PMC 15819  . PMID 10077561. doi:10.1073/pnas.96.6.2627. （原始内容存档于2022-06-16）（英语）.
^ Marcello, A. Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein. The EMBO Journal. 2003-05-01, 22 (9). PMC 156077  . PMID 12727882. doi:10.1093/emboj/cdg205.
^ Ishov, Alexander M.; Sotnikov, Alexey G.; Negorev, Dmitri; Vladimirova, Olga V.; Neff, Norma; Kamitani, Tetsu; Yeh, Edward T.H.; Strauss, Jerome F.; Maul, Gerd G. Pml Is Critical for Nd10 Formation and Recruits the Pml-Interacting Protein Daxx to This Nuclear Structure When Modified by Sumo-1. Journal of Cell Biology. 1999-10-18, 147 (2) [2022-06-16]. ISSN 0021-9525. PMC 2174231  . PMID 10525530. doi:10.1083/jcb.147.2.221. （原始内容存档于2022-06-16）（英语）.
^ Li, Hui; Leo, Christopher; Zhu, Jiang; Wu, Xiaoyang; O'Neil, Jennifer; Park, Eun-Ju; Chen, J. Don. Sequestration and Inhibition of Daxx-Mediated Transcriptional Repression by PML. Molecular and Cellular Biology. 2000-03, 20 (5) [2022-06-16]. ISSN 0270-7306. PMC 85360  . PMID 10669754. doi:10.1128/MCB.20.5.1784-1796.2000. （原始内容存档于2021-11-28）（英语）.
^ Lehembre, François; Müller, Stefan; Pandolfi, Pier Paolo; Dejean, Anne. Regulation of Pax3 transcriptional activity by SUMO-1-modified PML. Oncogene. 2001-01-04, 20 (1) [2022-06-16]. ISSN 0950-9232. PMID 11244500. doi:10.1038/sj.onc.1204063. （原始内容存档于2021-08-11）（英语）.
^ Zhong, Sue; Salomoni, Paolo; Ronchetti, Simona; Guo, Ailan; Ruggero, Davide; Pandolfi, Pier Paolo. Promyelocytic Leukemia Protein (Pml) and Daxx Participate in a Novel Nuclear Pathway for Apoptosis. Journal of Experimental Medicine. 2000-02-21, 191 (4) [2022-06-16]. ISSN 0022-1007. PMC 2195846  . PMID 10684855. doi:10.1084/jem.191.4.631. （原始内容存档于2022-06-16）（英语）.
^ Tsuzuki, Shinobu; Towatari, Masayuki; Saito, Hidehiko; Enver, Tariq. Potentiation of GATA-2 Activity through Interactions with the Promyelocytic Leukemia Protein (PML) and the t(15;17)-Generated PML-Retinoic Acid Receptor α Oncoprotein. Molecular and Cellular Biology. 2000-09, 20 (17) [2022-06-16]. ISSN 0270-7306. PMC 86102  . PMID 10938104. doi:10.1128/MCB.20.17.6276-6286.2000. （原始内容存档于2022-06-16）（英语）.
^ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Khan, M. M.; Nomura, T.; Kim, H.; Kaul, S. C.; Wadhwa, R.; Shinagawa, T.; Ichikawa-Iwata, E.; Zhong, S.; Pandolfi, P. P.; Ishii, S. Role of PML and PML-RARalpha in Mad-mediated transcriptional repression. Molecular Cell. 2001-06, 7 (6) [2022-06-16]. ISSN 1097-2765. PMID 11430826. doi:10.1016/s1097-2765(01)00257-x. （原始内容存档于2021-11-28）.
^ ^12.0 ^12.1 Wu, Wen-Shu; Vallian, Sadeq; Seto, Edward; Yang, Wen-Ming; Edmondson, Diane; Roth, Sharon; Chang, Kun-Sang. The Growth Suppressor PML Represses Transcription by Functionally and Physically Interacting with Histone Deacetylases. Molecular and Cellular Biology. 2001-04, 21 (7) [2022-06-16]. ISSN 0270-7306. PMC 86860  . PMID 11259576. doi:10.1128/MCB.21.7.2259-2268.2001. （原始内容存档于2022-06-16）（英语）.
^ Topcu, Zeki; Mack, David L; Hromas, Robert A; Borden, Katherine LB. The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control. Oncogene. 1999-11-25, 18 (50) [2022-06-16]. ISSN 0950-9232. PMID 10597310. doi:10.1038/sj.onc.1203201. （原始内容存档于2022-06-16）（英语）.
^ Shin, Jinwook; Park, Boyoun; Cho, Sunglim; Lee, Sunray; Kim, Youngkyun; Lee, Seong-Ok; Cho, Kwangmin; Lee, Sungwook; Jin, Bong-Suk; Ahn, Jin-Hyun; Choi, Eui-Ju. Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase. The Journal of Biological Chemistry. 2004-09-24, 279 (39) [2022-06-16]. ISSN 0021-9258. PMID 15273249. doi:10.1074/jbc.M407369200. （原始内容存档于2022-06-16）.
^ Dahle, Øyvind; Bakke, Oddmund; Gabrielsen, Odd Stokke. c-Myb associates with PML in nuclear bodies in hematopoietic cells. Experimental Cell Research. 2004-07-01, 297 (1) [2022-06-16]. ISSN 0014-4827. PMID 15194430. doi:10.1016/j.yexcr.2004.03.014. （原始内容存档于2022-06-16）.
^ ^16.0 ^16.1 Kurki, Sari; Latonen, Leena; Laiho, Marikki. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. Journal of Cell Science. 2003-10-01, 116 (19) [2022-06-16]. ISSN 1477-9137. PMID 12915590. doi:10.1242/jcs.00714. （原始内容存档于2022-06-16）（英语）.
^ ^17.0 ^17.1 Bernardi, Rosa; Scaglioni, Pier Paolo; Bergmann, Stephan; Horn, Henning F.; Vousden, Karen H.; Pandolfi, Pier Paolo. PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nature Cell Biology. 2004-07, 6 (7) [2022-06-16]. ISSN 1465-7392. PMID 15195100. doi:10.1038/ncb1147. （原始内容存档于2022-06-17）（英语）.
^ Zhu, Hongyan; Wu, Liqing; Maki, Carl G. MDM2 and promyelocytic leukemia antagonize each other through their direct interaction with p53. The Journal of Biological Chemistry. 2003-12-05, 278 (49) [2022-06-16]. ISSN 0021-9258. PMID 14507915. doi:10.1074/jbc.M308302200. （原始内容存档于2022-06-16）.
^ Wei, Xiaolong; Yu, Zhong Kang; Ramalingam, Arivudainambi; Grossman, Steven R.; Yu, Jiang H.; Bloch, Donald B.; Maki, Carl G. Physical and functional interactions between PML and MDM2. The Journal of Biological Chemistry. 2003-08-01, 278 (31) [2022-06-16]. ISSN 0021-9258. PMID 12759344. doi:10.1074/jbc.M212215200. （原始内容存档于2022-06-16）.
^ Wu, Wen-Shu; Xu, Zhi-Xiang; Ran, Ruixiang; Meng, Feng; Chang, Kun-Sang. Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions. Oncogene. 2002-05-30, 21 (24) [2022-06-16]. ISSN 0950-9232. PMID 12032831. doi:10.1038/sj.onc.1205491. （原始内容存档于2022-06-16）（英语）.
^ Hong, Suk-Hyun; Yang, Zhihong; Privalsky, Martin L. Arsenic Trioxide Is a Potent Inhibitor of the Interaction of SMRT Corepressor with Its Transcription Factor Partners, Including the PML-Retinoic Acid Receptor α Oncoprotein Found in Human Acute Promyelocytic Leukemia. Molecular and Cellular Biology. 2001-11, 21 (21) [2022-06-16]. ISSN 0270-7306. PMC 99892  . PMID 11585900. doi:10.1128/MCB.21.21.7172-7182.2001. （原始内容存档于2021-08-11）（英语）.
^ Fogal, V. Regulation of p53 activity in nuclear bodies by a specific PML isoform. The EMBO Journal. 2000-11-15, 19 (22). PMC 305840  . PMID 11080164. doi:10.1093/emboj/19.22.6185.
^ Guo, Ailan; Salomoni, Paolo; Luo, Jianyuan; Shih, Alan; Zhong, Sue; Gu, Wei; Paolo Pandolfi, Pier. The function of PML in p53-dependent apoptosis. Nature Cell Biology. 2000-10, 2 (10) [2022-06-16]. ISSN 1465-7392. PMID 11025664. doi:10.1038/35036365. （原始内容存档于2022-06-16）（英语）.
^ Alcalay, Myriam; Tomassoni, Lucia; Colombo, Emanuela; Stoldt, Stephan; Grignani, Francesco; Fagioli, Marta; Szekely, Laszlo; Helin, Kristian; Pelicci, Pier Giuseppe. The Promyelocytic Leukemia Gene Product (PML) Forms Stable Complexes with the Retinoblastoma Protein. Molecular and Cellular Biology. 1998-02, 18 (2) [2022-06-16]. ISSN 0270-7306. PMC 108821  . PMID 9448006. doi:10.1128/MCB.18.2.1084. （原始内容存档于2022-06-16）（英语）.
^ Kawasaki, Akira; Matsumura, Itaru; Kataoka, Yoshihisa; Takigawa, Eri; Nakajima, Koichi; Kanakura, Yuzuru. Opposing effects of PML and PML/RARα on STAT3 activity. Blood. 2003-05-01, 101 (9) [2022-06-16]. ISSN 1528-0020. PMID 12506013. doi:10.1182/blood-2002-08-2474. （原始内容存档于2022-06-16）（英语）.
^ Lin, Ding-Yen; Shih, Hsiu-Ming. Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration. The Journal of Biological Chemistry. 2002-07-12, 277 (28) [2022-06-16]. ISSN 0021-9258. PMID 11948183. doi:10.1074/jbc.M200633200. （原始内容存档于2022-06-20）.
^ Kamitani, T.; Nguyen, H. P.; Kito, K.; Fukuda-Kamitani, T.; Yeh, E. T. Covalent modification of PML by the sentrin family of ubiquitin-like proteins. The Journal of Biological Chemistry. 1998-02-06, 273 (6) [2022-06-16]. ISSN 0021-9258. PMID 9452416. doi:10.1074/jbc.273.6.3117. （原始内容存档于2022-06-20）.
^ Vallian, Sadeq; Chin, Khew-Voon; Chang, Kun-Sang. The Promyelocytic Leukemia Protein Interacts with Sp1 and Inhibits Its Transactivation of the Epidermal Growth Factor Receptor Promoter. Molecular and Cellular Biology. 1998-12, 18 (12) [2022-06-16]. ISSN 0270-7306. PMC 109296  . PMID 9819401. doi:10.1128/MCB.18.12.7147. （原始内容存档于2022-06-16）（英语）.
^ Xu, Zhi-Xiang; Timanova-Atanasova, Anna; Zhao, Rui-Xun; Chang, Kun-Sang. PML Colocalizes with and Stabilizes the DNA Damage Response Protein TopBP1. Molecular and Cellular Biology. 2003-06-15, 23 (12). ISSN 0270-7306. PMC 156140  . PMID 12773567. doi:10.1128/MCB.23.12.4247-4256.2003 （英语）.
^ Takahashi, Hidehisa; Hatakeyama, Shigetsugu; Saitoh, Hisato; Nakayama, Keiichi I. Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein. The Journal of Biological Chemistry. 2005-02-18, 280 (7) [2022-06-16]. ISSN 0021-9258. PMID 15569683. doi:10.1074/jbc.M408130200. （原始内容存档于2022-06-16）.
^ Koken, M. H. M.; Reid, A.; Quignon, F.; Chelbi-Alix, M. K.; Davies, J. M.; Kabarowski, J. H. S.; Zhu, J.; Dong, S.; Chen, S.-J.; Chen, Z.; Tan, C. C. Leukemia-associated retinoic acid receptor α fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. Proceedings of the National Academy of Sciences. 1997-09-16, 94 (19) [2022-06-16]. ISSN 0027-8424. PMC 23349  . PMID 9294197. doi:10.1073/pnas.94.19.10255. （原始内容存档于2022-06-16）（英语）.

延伸阅读编辑

Zhong, Sue; Salomoni, Paolo; Pandolfi, Pier Paolo. The transcriptional role of PML and the nuclear body. Nature Cell Biology. 2000-05, 2 (5) [2022-06-16]. ISSN 1465-7392. PMID 10806494. doi:10.1038/35010583. （原始内容存档于2022-03-10）（英语）.
Jensen, Kirsten; Shiels, Carol; Freemont, Paul S. PML protein isoforms and the RBCC/TRIM motif. Oncogene. 2001-10-29, 20 (49) [2022-06-16]. ISSN 0950-9232. PMID 11704850. doi:10.1038/sj.onc.1204765. （原始内容存档于2022-05-25）（英语）.
Pearson, Mark; Pelicci, Pier Giuseppe. PML interaction with p53 and its role in apoptosis and replicative senescence. Oncogene. 2001-10-29, 20 (49) [2022-06-16]. ISSN 0950-9232. PMID 11704853. doi:10.1038/sj.onc.1204856. （原始内容存档于2022-06-16）（英语）. >
Salomoni, Paolo; Pandolfi, Pier Paolo. The role of PML in tumor suppression. Cell. 2002-01-25, 108 (2) [2022-06-16]. ISSN 0092-8674. PMID 11832207. doi:10.1016/s0092-8674(02)00626-8. （原始内容存档于2022-03-02）.
Combes, Robert; Balls, Michael; Bansil, Lee; Barratt, Martin; Bell, David; Botham, Phil; Broadhead, Caren; Clothier, Richard; George, Elizabeth; Fentem, Julia; Jackson, Michael. An Assessment of Progress in the Use of Alternatives in Toxicity Testing since the Publication of the Report of the Second FRAME Toxicity Committee (1991). Alternatives to Laboratory Animals. 2002-07, 30 (4) [2022-06-16]. ISSN 0261-1929. PMID 12234245. doi:10.1177/026119290203000403. （原始内容存档于2021-08-10）（英语）.
Bernardi, Rosa; Pandolfi, Pier Paolo. Role of PML and the PML-nuclear body in the control of programmed cell death. Oncogene. 2003-12-08, 22 (56) [2022-06-16]. ISSN 0950-9232. PMID 14663483. doi:10.1038/sj.onc.1207106. （原始内容存档于2022-06-16）（英语）.
Beez, Sabine; Demmer, Philipp; Puccetti, Elena. Tse, William , 编. Targeting the Acute Promyelocytic Leukemia-Associated Fusion Proteins PML/RARα and PLZF/RARα with Interfering Peptides. PLoS ONE. 2012-11-09, 7 (11). ISSN 1932-6203. PMC 3494703  . PMID 23152790. doi:10.1371/journal.pone.0048636 （英语）.

外部链接编辑

醫學主題詞表（MeSH）：PML+protein,+human

[pmid15136035-1] Kojic, Snezana; Medeot, Elisa; Guccione, Ernesto; Krmac, Helena; Zara, Ivano; Martinelli, Valentina; Valle, Giorgio; Faulkner, Georgine. The Ankrd2 Protein, a Link Between the Sarcomere and the Nucleus in Skeletal Muscle. Journal of Molecular Biology. 2004-05, 339 (2) [2022-06-16]. doi:10.1016/j.jmb.2004.03.071. （原始内容存档于2022-06-15）（英语）.

[pmid10610177-2] 2.0 ^2.1 Zhong, Sue; Delva, Laurent; Rachez, Christophe; Cenciarelli, Cristina; Gandini, Domenica; Zhang, Hui; Kalantry, Sundeep; Freedman, Leonard P.; Pandolfi, Pier Paolo. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARα and T18 oncoproteins. Nature Genetics. 1999-11, 23 (3) [2022-06-16]. ISSN 1061-4036. PMID 10610177. doi:10.1038/15463. （原始内容存档于2022-03-10）（英语）.

[pmid12622724-3] 3.0 ^3.1 Matsuzaki, Kazuhito; Minami, Takeshi; Tojo, Masahide; Honda, Yoshiomi; Saitoh, Noriko; Nagahiro, Shinji; Saya, Hideyuki; Nakao, Mitsuyoshi. PML-nuclear bodies are involved in cellular serum response. Genes to Cells: Devoted to Molecular & Cellular Mechanisms. 2003-03, 8 (3) [2022-06-16]. ISSN 1356-9597. PMID 12622724. doi:10.1046/j.1365-2443.2003.00632.x. （原始内容存档于2022-06-16）.

[pmid10077561-4] Doucas, Vassilis; Tini, Marc; Egan, David A.; Evans, Ronald M. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. Proceedings of the National Academy of Sciences. 1999-03-16, 96 (6) [2022-06-16]. ISSN 0027-8424. PMC 15819  . PMID 10077561. doi:10.1073/pnas.96.6.2627. （原始内容存档于2022-06-16）（英语）.

[pmid12727882-5] Marcello, A. Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein. The EMBO Journal. 2003-05-01, 22 (9). PMC 156077  . PMID 12727882. doi:10.1093/emboj/cdg205.

[pmid10525530-6] Ishov, Alexander M.; Sotnikov, Alexey G.; Negorev, Dmitri; Vladimirova, Olga V.; Neff, Norma; Kamitani, Tetsu; Yeh, Edward T.H.; Strauss, Jerome F.; Maul, Gerd G. Pml Is Critical for Nd10 Formation and Recruits the Pml-Interacting Protein Daxx to This Nuclear Structure When Modified by Sumo-1. Journal of Cell Biology. 1999-10-18, 147 (2) [2022-06-16]. ISSN 0021-9525. PMC 2174231  . PMID 10525530. doi:10.1083/jcb.147.2.221. （原始内容存档于2022-06-16）（英语）.

[pmid10669754-7] Li, Hui; Leo, Christopher; Zhu, Jiang; Wu, Xiaoyang; O'Neil, Jennifer; Park, Eun-Ju; Chen, J. Don. Sequestration and Inhibition of Daxx-Mediated Transcriptional Repression by PML. Molecular and Cellular Biology. 2000-03, 20 (5) [2022-06-16]. ISSN 0270-7306. PMC 85360  . PMID 10669754. doi:10.1128/MCB.20.5.1784-1796.2000. （原始内容存档于2021-11-28）（英语）.

[pmid11244500-8] Lehembre, François; Müller, Stefan; Pandolfi, Pier Paolo; Dejean, Anne. Regulation of Pax3 transcriptional activity by SUMO-1-modified PML. Oncogene. 2001-01-04, 20 (1) [2022-06-16]. ISSN 0950-9232. PMID 11244500. doi:10.1038/sj.onc.1204063. （原始内容存档于2021-08-11）（英语）.

[pmid10684855-9] Zhong, Sue; Salomoni, Paolo; Ronchetti, Simona; Guo, Ailan; Ruggero, Davide; Pandolfi, Pier Paolo. Promyelocytic Leukemia Protein (Pml) and Daxx Participate in a Novel Nuclear Pathway for Apoptosis. Journal of Experimental Medicine. 2000-02-21, 191 (4) [2022-06-16]. ISSN 0022-1007. PMC 2195846  . PMID 10684855. doi:10.1084/jem.191.4.631. （原始内容存档于2022-06-16）（英语）.

[pmid10938104-10] Tsuzuki, Shinobu; Towatari, Masayuki; Saito, Hidehiko; Enver, Tariq. Potentiation of GATA-2 Activity through Interactions with the Promyelocytic Leukemia Protein (PML) and the t(15;17)-Generated PML-Retinoic Acid Receptor α Oncoprotein. Molecular and Cellular Biology. 2000-09, 20 (17) [2022-06-16]. ISSN 0270-7306. PMC 86102  . PMID 10938104. doi:10.1128/MCB.20.17.6276-6286.2000. （原始内容存档于2022-06-16）（英语）.

[pmid11430826-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Khan, M. M.; Nomura, T.; Kim, H.; Kaul, S. C.; Wadhwa, R.; Shinagawa, T.; Ichikawa-Iwata, E.; Zhong, S.; Pandolfi, P. P.; Ishii, S. Role of PML and PML-RARalpha in Mad-mediated transcriptional repression. Molecular Cell. 2001-06, 7 (6) [2022-06-16]. ISSN 1097-2765. PMID 11430826. doi:10.1016/s1097-2765(01)00257-x. （原始内容存档于2021-11-28）.

[pmid11259576-12] 12.0 ^12.1 Wu, Wen-Shu; Vallian, Sadeq; Seto, Edward; Yang, Wen-Ming; Edmondson, Diane; Roth, Sharon; Chang, Kun-Sang. The Growth Suppressor PML Represses Transcription by Functionally and Physically Interacting with Histone Deacetylases. Molecular and Cellular Biology. 2001-04, 21 (7) [2022-06-16]. ISSN 0270-7306. PMC 86860  . PMID 11259576. doi:10.1128/MCB.21.7.2259-2268.2001. （原始内容存档于2022-06-16）（英语）.

[pmid10597310-13] Topcu, Zeki; Mack, David L; Hromas, Robert A; Borden, Katherine LB. The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control. Oncogene. 1999-11-25, 18 (50) [2022-06-16]. ISSN 0950-9232. PMID 10597310. doi:10.1038/sj.onc.1203201. （原始内容存档于2022-06-16）（英语）.

[pmid15273249-14] Shin, Jinwook; Park, Boyoun; Cho, Sunglim; Lee, Sunray; Kim, Youngkyun; Lee, Seong-Ok; Cho, Kwangmin; Lee, Sungwook; Jin, Bong-Suk; Ahn, Jin-Hyun; Choi, Eui-Ju. Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase. The Journal of Biological Chemistry. 2004-09-24, 279 (39) [2022-06-16]. ISSN 0021-9258. PMID 15273249. doi:10.1074/jbc.M407369200. （原始内容存档于2022-06-16）.

[pmid15194430-15] Dahle, Øyvind; Bakke, Oddmund; Gabrielsen, Odd Stokke. c-Myb associates with PML in nuclear bodies in hematopoietic cells. Experimental Cell Research. 2004-07-01, 297 (1) [2022-06-16]. ISSN 0014-4827. PMID 15194430. doi:10.1016/j.yexcr.2004.03.014. （原始内容存档于2022-06-16）.

[pmid12915590-16] 16.0 ^16.1 Kurki, Sari; Latonen, Leena; Laiho, Marikki. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. Journal of Cell Science. 2003-10-01, 116 (19) [2022-06-16]. ISSN 1477-9137. PMID 12915590. doi:10.1242/jcs.00714. （原始内容存档于2022-06-16）（英语）.

[pmid15195100-17] 17.0 ^17.1 Bernardi, Rosa; Scaglioni, Pier Paolo; Bergmann, Stephan; Horn, Henning F.; Vousden, Karen H.; Pandolfi, Pier Paolo. PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nature Cell Biology. 2004-07, 6 (7) [2022-06-16]. ISSN 1465-7392. PMID 15195100. doi:10.1038/ncb1147. （原始内容存档于2022-06-17）（英语）.

[pmid14507915-18] Zhu, Hongyan; Wu, Liqing; Maki, Carl G. MDM2 and promyelocytic leukemia antagonize each other through their direct interaction with p53. The Journal of Biological Chemistry. 2003-12-05, 278 (49) [2022-06-16]. ISSN 0021-9258. PMID 14507915. doi:10.1074/jbc.M308302200. （原始内容存档于2022-06-16）.

[pmid12759344-19] Wei, Xiaolong; Yu, Zhong Kang; Ramalingam, Arivudainambi; Grossman, Steven R.; Yu, Jiang H.; Bloch, Donald B.; Maki, Carl G. Physical and functional interactions between PML and MDM2. The Journal of Biological Chemistry. 2003-08-01, 278 (31) [2022-06-16]. ISSN 0021-9258. PMID 12759344. doi:10.1074/jbc.M212215200. （原始内容存档于2022-06-16）.

[pmid12032831-20] Wu, Wen-Shu; Xu, Zhi-Xiang; Ran, Ruixiang; Meng, Feng; Chang, Kun-Sang. Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions. Oncogene. 2002-05-30, 21 (24) [2022-06-16]. ISSN 0950-9232. PMID 12032831. doi:10.1038/sj.onc.1205491. （原始内容存档于2022-06-16）（英语）.

[pmid11585900-21] Hong, Suk-Hyun; Yang, Zhihong; Privalsky, Martin L. Arsenic Trioxide Is a Potent Inhibitor of the Interaction of SMRT Corepressor with Its Transcription Factor Partners, Including the PML-Retinoic Acid Receptor α Oncoprotein Found in Human Acute Promyelocytic Leukemia. Molecular and Cellular Biology. 2001-11, 21 (21) [2022-06-16]. ISSN 0270-7306. PMC 99892  . PMID 11585900. doi:10.1128/MCB.21.21.7172-7182.2001. （原始内容存档于2021-08-11）（英语）.

[pmid11080164-22] Fogal, V. Regulation of p53 activity in nuclear bodies by a specific PML isoform. The EMBO Journal. 2000-11-15, 19 (22). PMC 305840  . PMID 11080164. doi:10.1093/emboj/19.22.6185.

[pmid11025664-23] Guo, Ailan; Salomoni, Paolo; Luo, Jianyuan; Shih, Alan; Zhong, Sue; Gu, Wei; Paolo Pandolfi, Pier. The function of PML in p53-dependent apoptosis. Nature Cell Biology. 2000-10, 2 (10) [2022-06-16]. ISSN 1465-7392. PMID 11025664. doi:10.1038/35036365. （原始内容存档于2022-06-16）（英语）.

[pmid9448006-24] Alcalay, Myriam; Tomassoni, Lucia; Colombo, Emanuela; Stoldt, Stephan; Grignani, Francesco; Fagioli, Marta; Szekely, Laszlo; Helin, Kristian; Pelicci, Pier Giuseppe. The Promyelocytic Leukemia Gene Product (PML) Forms Stable Complexes with the Retinoblastoma Protein. Molecular and Cellular Biology. 1998-02, 18 (2) [2022-06-16]. ISSN 0270-7306. PMC 108821  . PMID 9448006. doi:10.1128/MCB.18.2.1084. （原始内容存档于2022-06-16）（英语）.

[pmid12506013-25] Kawasaki, Akira; Matsumura, Itaru; Kataoka, Yoshihisa; Takigawa, Eri; Nakajima, Koichi; Kanakura, Yuzuru. Opposing effects of PML and PML/RARα on STAT3 activity. Blood. 2003-05-01, 101 (9) [2022-06-16]. ISSN 1528-0020. PMID 12506013. doi:10.1182/blood-2002-08-2474. （原始内容存档于2022-06-16）（英语）.

[pmid11948183-26] Lin, Ding-Yen; Shih, Hsiu-Ming. Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration. The Journal of Biological Chemistry. 2002-07-12, 277 (28) [2022-06-16]. ISSN 0021-9258. PMID 11948183. doi:10.1074/jbc.M200633200. （原始内容存档于2022-06-20）.

[pmid9452416-27] Kamitani, T.; Nguyen, H. P.; Kito, K.; Fukuda-Kamitani, T.; Yeh, E. T. Covalent modification of PML by the sentrin family of ubiquitin-like proteins. The Journal of Biological Chemistry. 1998-02-06, 273 (6) [2022-06-16]. ISSN 0021-9258. PMID 9452416. doi:10.1074/jbc.273.6.3117. （原始内容存档于2022-06-20）.

[pmid9819401-28] Vallian, Sadeq; Chin, Khew-Voon; Chang, Kun-Sang. The Promyelocytic Leukemia Protein Interacts with Sp1 and Inhibits Its Transactivation of the Epidermal Growth Factor Receptor Promoter. Molecular and Cellular Biology. 1998-12, 18 (12) [2022-06-16]. ISSN 0270-7306. PMC 109296  . PMID 9819401. doi:10.1128/MCB.18.12.7147. （原始内容存档于2022-06-16）（英语）.

[pmid12773567-29] Xu, Zhi-Xiang; Timanova-Atanasova, Anna; Zhao, Rui-Xun; Chang, Kun-Sang. PML Colocalizes with and Stabilizes the DNA Damage Response Protein TopBP1. Molecular and Cellular Biology. 2003-06-15, 23 (12). ISSN 0270-7306. PMC 156140  . PMID 12773567. doi:10.1128/MCB.23.12.4247-4256.2003 （英语）.

[pmid15569683-30] Takahashi, Hidehisa; Hatakeyama, Shigetsugu; Saitoh, Hisato; Nakayama, Keiichi I. Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein. The Journal of Biological Chemistry. 2005-02-18, 280 (7) [2022-06-16]. ISSN 0021-9258. PMID 15569683. doi:10.1074/jbc.M408130200. （原始内容存档于2022-06-16）.

[pmid9294197-31] Koken, M. H. M.; Reid, A.; Quignon, F.; Chelbi-Alix, M. K.; Davies, J. M.; Kabarowski, J. H. S.; Zhu, J.; Dong, S.; Chen, S.-J.; Chen, Z.; Tan, C. C. Leukemia-associated retinoic acid receptor α fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. Proceedings of the National Academy of Sciences. 1997-09-16, 94 (19) [2022-06-16]. ISSN 0027-8424. PMC 23349  . PMID 9294197. doi:10.1073/pnas.94.19.10255. （原始内容存档于2022-06-16）（英语）.

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早幼粒细胞白血病蛋白

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