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初始B細胞(naive B cell / virgin B cell)係一類還未與抗原接觸的B細胞。一旦與抗原接觸,它就會增殖分化爲記憶B細胞或者能產生能與刺激它的抗原特異性結合的抗體漿細胞。與壽命不長的漿細胞不同,記憶B細胞不能產生抗體,但能夠長期存活,並能在同種抗原再次入侵時,迅速增殖分化爲能產生大量抗體的漿細胞和新的記憶細胞[1][2]

參考编辑

  1. ^ Airoldi I, Raffaghello L, Cocco C; 等. Heterogeneous expression of interleukin-18 and its receptor in B-cell lymphoproliferative disorders deriving from naive, germinal center, and memory B lymphocytes. Clin. Cancer Res. January 2004, 10 (1 Pt 1): 144–54. PMID 14734463. doi:10.1158/1078-0432.CCR-1026-3. 
  2. ^ Lang ML. How do natural killer T cells help B cells?. Expert Rev Vaccines. Aug 2009, 8 (8): 1109–21. PMC 2747240. PMID 19627191. doi:10.1586/erv.09.56.