磷酸甘油酸变位酶

磷酸甘油酸变位酶(英語:Phosphoglycerate mutasePGMEC 5.4.2.11)是一种催化3-磷酸甘油酸(3PG)转变为2-磷酸甘油酸(2PG)的酶,这个反应糖酵解途径的第八步,其中间产物是2,3-二磷酸甘油酸(2,3BPG)反应式如下:[1][2][3]

Phosphoglycerate mutase family
鑑定
標誌PGAM
PfamPF00300
InterPro英语InterProIPR013078
PROSITE英语PROSITEPDOC00158
SCOP英语Structural Classification of Proteins3pgm / SUPFAM
phosphoglycerate mutase 1 (brain)
Homodimer B-type PGM.png
識別
符號 PGAM1
替換符號 PGAMA
Entrez 5223
HUGO 8888
OMIM 172250
RefSeq NM_002629
UniProt P18669
其他資料
EC編號 5.4.2.11
基因座 10 q25.3
phosphoglycerate mutase 2 (muscle)
識別
符號 PGAM2
Entrez 5224
HUGO 8889
OMIM 261670
RefSeq NM_000290
UniProt P15259
其他資料
EC編號 5.4.2.11
基因座 7 p13-p12
3PG + P-Enzyme → 2,3BPG + Enzyme → 2PG + P-Enzyme

ΔG°′=+1.1kcal/mol

参考文献编辑

  1. ^ Johnsen, U; Schönheit, P. Characterization of cofactor-dependent and cofactor-independent phosphoglycerate mutases from Archaea.. Extremophiles : life under extreme conditions. September 2007, 11 (5): 647–57. PMID 17576516. doi:10.1007/s00792-007-0094-x. 
  2. ^ Jedrzejas, MJ. Structure, function, and evolution of phosphoglycerate mutases: comparison with fructose-2,6-bisphosphatase, acid phosphatase, and alkaline phosphatase.. Progress in biophysics and molecular biology. 2000, 73 (2–4): 263–87. PMID 10958932. doi:10.1016/s0079-6107(00)00007-9. 
  3. ^ Galperin, MY; Bairoch, A; Koonin, EV. A superfamily of metalloenzymes unifies phosphopentomutase and cofactor-independent phosphoglycerate mutase with alkaline phosphatases and sulfatases.. Protein Science. August 1998, 7 (8): 1829–35. PMC 2144072 . PMID 10082381. doi:10.1002/pro.5560070819. 

外部連結编辑