福山吲哚合成

Fukuyama吲哚合成(福山吲哚合成,Fukuyama indole synthesis),由日本化学家福山透(Fukuyama Tohru)发现。[1]

烯基硫代酰基苯胺AIBN三丁基氢化锡体系作用下,环化为2,3-二取代吲哚[2]


Fukuyama吲哚合成
Fukuyama吲哚合成


用于含多取代吲哚结构的天然产物合成,如 aspidophytine[3]长春碱[4]番木鳖碱[5]

参见 编辑

参考资料 编辑

  1. ^ Fukuyama, T.; Chen, X.; Peng, G. J. Am. Chem. Soc. 1994, 116, 3127-3128. DOI: 10.1021/ja00086a054
  2. ^ Tokuyama, H; Yamashita, T; Reding, M. T; Kaburagi, Y; Fukuyama, T. Radical Cyclization of 2-Alkenylthioanilides: A Novel Synthesis of 2,3-Disubstituted Indoles. J. Am. Chem. Soc. 1999, 121: 3791–3792. doi:10.1021/ja983681v. 
  3. ^ Sumi, S; Matsumoto, K; Tokuyama, H; Fukuyama, T. Enantioselective Total Synthesis of Aspidophytine. Org. Lett. 2003, 5 (11): 1891–1893. PMID 12762679. doi:10.1021/ol034445e. 
  4. ^ Yokoshima, S; Ueda, T; Kobayashi, S; Sato, A; Kuboyama, T; Tokuyama, H; Fukuyama, T. Stereocontrolled Total Synthesis of (+)-Vinblastine. J. Am. Chem. Soc. 2002, 124: 2137–2139. doi:10.1021/ja0177049. 
  5. ^ Kaburagi, Y; Tokuyama, H; Fukuyama, T. Total Synthesis of (-)-Strychnine. J. Am. Chem. Soc. 2004, 126 (33): 10246–10247. PMID 15315428. doi:10.1021/ja046407b.