芳香化酶
芳香化酶(英語:Aromatase)也被称为雌激素合成酶(estrogen synthetase)是雌激素生物合成的关键酶,在人体内由基因 CYP19A1 编码,是细胞色素P450超家族的一员,EC 1.14.14.1。芳香化酶是一种单加氧酶,催化涉及甾体激素合成步骤中从雄激素到雌激素的芳香化反应。芳香化酶在许多人体组织中出现,如生殖腺(颗粒细胞)、脑、脂肪組織、胎盤、血管、皮膚和骨骼,对青春期的第二性征发育有重要作用。
催化机理编辑
参考文献编辑
- ^ 與芳香酶相關的疾病;在維基數據上查看/編輯參考.
- ^ 對芳香酶起作用的藥物;在維基數據上查看/編輯參考.
- ^ 3.0 3.1 3.2 GRCh38: Ensembl release 89: ENSG00000137869 - Ensembl, May 2017
- ^ 4.0 4.1 4.2 GRCm38: Ensembl release 89: ENSMUSG00000032274 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Vaz AD. Chapter 1: Cytochrome activation by cytochromes P450: a role for multiple oxidants in the oxidation of substrates. Fisher M, Lee JK, Obach RE (编). Drug metabolizing enzymes: cytochrome P450 and other enzymes in drug discovery and development. Lausanne, Switzerland: FontisMedia SA. 2003. ISBN 978-0-8247-4293-5.
外部链接编辑
- "U.S. study of gay sheep may shed light on sexuality", via WikiNews, 15 August 2005.
- Human CYP19A1 genome location and CYP19A1 gene details page in the UCSC Genome Browser.