苯乙酰胺

苯乙酰胺
英文名	Benzeneacetamide
识别
CAS号	103-81-1
性质
化学式	C8H9NO
摩尔质量	135.16 g·mol−1
熔点	156—158 °C（429—431 K）
沸点	240 °C（513 K）（5 torr）
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

苯乙酰胺是一种有机化合物，化学式为C₈H₉NO。它可由苯乙腈在碱性条件下水解制得。^[3]它和劳森试剂反应，可以得到硫代苯乙酰胺。^[4]它和二乙酸碘苯、氨在甲醇中反应，可以得到苄脲。^[5]在氧化汞的存在下，它和二溴海因（英语：DBDMH）在DMF中反应，可以得到苄基氨基甲酸甲酯。^[6]

参考文献编辑

^ Distler, Harry; Kutepow, Nikolaus v. Kutepow. Carbonamides. 1959. DE 1060379.
^ Ken'ichi Takeda, Kanji Tokuyama. Studies on the Reaction of Caustic Alkali in Nonaqueous Solutions. II.: Reactions with Nitriles. (2). YAKUGAKU ZASSHI. 1956, 76 (1): 77–79 [2021-10-11]. ISSN 0031-6903. doi:10.1248/yakushi1947.76.1_77. （原始内容存档于2018-06-05）（英语）.
^ Marie Charlotte Koffi-Bié Djoman, Abdelaziz Nait Ajjou. The hydration of nitriles catalyzed by water-soluble rhodium complexes. Tetrahedron Letters. 2000-06, 41 (25): 4845–4849 [2021-10-11]. doi:10.1016/S0040-4039(00)00743-7. （原始内容存档于2018-06-30）（英语）.
^ Gibeom Nam, Jun Min Jung, Hyun-Ju Park, Seung Yeop Baek, Ki Seon Baek, Hui yeon Mok, Da Eun Kim, Young Hoon Jung. Structure-activity relationship study of thiazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors. Bioorganic & Medicinal Chemistry. 2019-08, 27 (15): 3408–3420 [2021-10-11]. doi:10.1016/j.bmc.2019.06.036 （英语）.
^ Nathalie Saraiva Rosa, Thomas Glachet, Quentin Ibert, Jean-François Lohier, Xavier Franck, Vincent Reboul. A Straightforward Synthesis of N-Substituted Ureas from Primary Amides. Synthesis. 2020-07, 52 (14): 2099–2105 [2021-10-11]. ISSN 0039-7881. doi:10.1055/s-0040-1707103 （英语）.
^ Sang-sup Jew, Hyeung Geun Park, Myoung-hee Kang, Tae-hee Lee, Youn-sang Cho. Practical hofmann rearrangement. Archives of Pharmacal Research. 1992-12, 15 (4): 333–335 [2021-10-11]. ISSN 0253-6269. doi:10.1007/BF02974108 （英语）.

[1] Distler, Harry; Kutepow, Nikolaus v. Kutepow. Carbonamides. 1959. DE 1060379.

[2] Ken'ichi Takeda, Kanji Tokuyama. Studies on the Reaction of Caustic Alkali in Nonaqueous Solutions. II.: Reactions with Nitriles. (2). YAKUGAKU ZASSHI. 1956, 76 (1): 77–79 [2021-10-11]. ISSN 0031-6903. doi:10.1248/yakushi1947.76.1_77. （原始内容存档于2018-06-05）（英语）.

[3] Marie Charlotte Koffi-Bié Djoman, Abdelaziz Nait Ajjou. The hydration of nitriles catalyzed by water-soluble rhodium complexes. Tetrahedron Letters. 2000-06, 41 (25): 4845–4849 [2021-10-11]. doi:10.1016/S0040-4039(00)00743-7. （原始内容存档于2018-06-30）（英语）.

[4] Gibeom Nam, Jun Min Jung, Hyun-Ju Park, Seung Yeop Baek, Ki Seon Baek, Hui yeon Mok, Da Eun Kim, Young Hoon Jung. Structure-activity relationship study of thiazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors. Bioorganic & Medicinal Chemistry. 2019-08, 27 (15): 3408–3420 [2021-10-11]. doi:10.1016/j.bmc.2019.06.036 （英语）.

[5] Nathalie Saraiva Rosa, Thomas Glachet, Quentin Ibert, Jean-François Lohier, Xavier Franck, Vincent Reboul. A Straightforward Synthesis of N-Substituted Ureas from Primary Amides. Synthesis. 2020-07, 52 (14): 2099–2105 [2021-10-11]. ISSN 0039-7881. doi:10.1055/s-0040-1707103 （英语）.

[6] Sang-sup Jew, Hyeung Geun Park, Myoung-hee Kang, Tae-hee Lee, Youn-sang Cho. Practical hofmann rearrangement. Archives of Pharmacal Research. 1992-12, 15 (4): 333–335 [2021-10-11]. ISSN 0253-6269. doi:10.1007/BF02974108 （英语）.

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苯乙酰胺

参考文献 编辑

参考文献编辑