苯乙酰胺

化合物

苯乙酰胺是一种有机化合物,化学式为C8H9NO。它可由苯乙腈在碱性条件下水解制得。[3]它和劳森试剂反应,可以得到硫代苯乙酰胺。[4]它和二乙酸碘苯英语(Diacetoxyiodo)benzene、氨在甲醇中反应,可以得到苄脲。[5]氧化汞的存在下,它和二溴海因英语DBDMH在DMF中反应,可以得到苄基氨基甲酸甲酯。[6]

苯乙酰胺
英文名 Benzeneacetamide
识别
CAS号 103-81-1  ✓
性质
化学式 C8H9NO
摩尔质量 135.16 g·mol−1
熔点 156-158 °C(429-431 K)[1]
沸点 240 °C(513 K)(5 torr)[2]
若非注明,所有数据均出自一般条件(25 ℃,100 kPa)下。

参考文献编辑

  1. ^ Distler, Harry; Kutepow, Nikolaus v. Kutepow. Carbonamides. 1959. DE 1060379.
  2. ^ Ken'ichi Takeda, Kanji Tokuyama. Studies on the Reaction of Caustic Alkali in Nonaqueous Solutions. II.: Reactions with Nitriles. (2). YAKUGAKU ZASSHI. 1956, 76 (1): 77–79 [2021-10-11]. ISSN 0031-6903. doi:10.1248/yakushi1947.76.1_77. (原始内容存档于2018-06-05) (英语). 
  3. ^ Marie Charlotte Koffi-Bié Djoman, Abdelaziz Nait Ajjou. The hydration of nitriles catalyzed by water-soluble rhodium complexes. Tetrahedron Letters. 2000-06, 41 (25): 4845–4849 [2021-10-11]. doi:10.1016/S0040-4039(00)00743-7. (原始内容存档于2018-06-30) (英语). 
  4. ^ Gibeom Nam, Jun Min Jung, Hyun-Ju Park, Seung Yeop Baek, Ki Seon Baek, Hui yeon Mok, Da Eun Kim, Young Hoon Jung. Structure-activity relationship study of thiazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors. Bioorganic & Medicinal Chemistry. 2019-08, 27 (15): 3408–3420 [2021-10-11]. doi:10.1016/j.bmc.2019.06.036 (英语). 
  5. ^ Nathalie Saraiva Rosa, Thomas Glachet, Quentin Ibert, Jean-François Lohier, Xavier Franck, Vincent Reboul. A Straightforward Synthesis of N-Substituted Ureas from Primary Amides. Synthesis. 2020-07, 52 (14): 2099–2105 [2021-10-11]. ISSN 0039-7881. doi:10.1055/s-0040-1707103 (英语). 
  6. ^ Sang-sup Jew, Hyeung Geun Park, Myoung-hee Kang, Tae-hee Lee, Youn-sang Cho. Practical hofmann rearrangement. Archives of Pharmacal Research. 1992-12, 15 (4): 333–335 [2021-10-11]. ISSN 0253-6269. doi:10.1007/BF02974108 (英语).