血清素轉運體

血清素轉運體, 5-羥色胺轉運體 (SERT 或 5-HTT)，鈉離子依賴型血清素轉運體 及 溶質載體家族6成員4 是一種在人體中被SLC6A4基因所編碼的蛋白質。SERT 是一種負責傳送突觸間隙的血清素到突觸前神經元的單胺轉運蛋白。

Solute carrier family 6 (neurotransmitter transporter), member 4
标识
代号	SLC6A4; 5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT
扩展标识	遗传学：182138 鼠基因：96285 同源基因：817 ChEMBL: 228 GeneCards: SLC6A4 Gene
基因本体论描述 分子功能 · serotonin:sodium symporter activity · protein binding · monoamine transmembrane transporter activity · serotonin transmembrane transporter activity · myosin binding · syntaxin-1 binding · Rab GTPase binding · cocaine binding · protein homodimerization activity · nitric-oxide synthase binding · actin filament binding 细胞成分 · cytosol · plasma membrane · integral component of plasma membrane · endosome membrane · endomembrane system · neuron projection · membrane raft 生物过程 · response to hypoxia · serotonin transport · synaptic transmission · response to nutrient · memory · circadian rhythm · response to toxic substance · positive regulation of gene expression · monoamine transport · thalamus development · negative regulation of cerebellar granule cell precursor proliferation · negative regulation of synaptic transmission, dopaminergic · response to estradiol · social behavior · vasoconstriction · response to drug · sperm ejaculation · negative regulation of neuron differentiation · positive regulation of cell cycle · negative regulation of organ growth · brain morphogenesis · protein oligomerization · protein homooligomerization · serotonin uptake · transmembrane transport · cellular response to retinoic acid · cellular response to cGMP Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	6532	15567
Ensembl	ENSG00000108576	ENSMUSG00000020838
UniProt	P31645	Q60857
mRNA序列	NM_001045	NM_010484
蛋白序列	NP_001036	NP_034614
基因位置	Chr 17: 30.19 – 30.24 Mb	Chr 11: 77 – 77.03 Mb
PubMed查询	[1]	[2]

功能

血清素轉運體將血清素從突觸間隙發送回突触终扣，阻止了血清素的作用，同時令突觸前神經元能夠重新運用突觸間隙的血清素。

神經元之間的溝通是由神經傳導物質，如細胞之間的血清素轉運來進行。因血清素轉運體使血清素得以重新運用；平衝了血清素於突觸間隙的濃度，因此其作用於接收神經元的受體上。

血清素轉運體也存在於血小板中，作用為一種使血管收縮的物質。

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  血清素