1-异硫氰基-6-甲亚磺酰基己烷
化合物
1-异硫氰基-6-甲亚磺酰基己烷或异硫氰酸-6-甲亚磺酰基己酯是一种有机化合物，化学式为C8H15NOS2。它可由6-溴己腈、甲硫醇钠、二硫化碳和间氯过氧苯甲酸为原料反应得到。[1]它存在于山葵中，是一种糖原合酶激酶3β抑制剂。[2]有文献对其抗癌作用做了小鼠实验。[3]
| 1-异硫氰基-6-甲亚磺酰基己烷 | |
|---|---|
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| |
| IUPAC名 1-Isothiocyanato-6-(methanesulfinyl)hexane | |
| 别名 | 6-MITC; 6-MSITC 异硫氰酸(6-甲亚磺酰基)己酯 (6-甲基亚磺酰基)己基硫氰酸酯 |
| 识别 | |
| CAS号 | 4430-35-7 
|
| PubChem | 9815648 |
| ChemSpider | 7991398 |
| SMILES |
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| ChEBI | 138799 |
| 性质 | |
| 化学式 | C8H15NOS2 |
| 摩尔质量 | 205.34 g·mol−1 |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
参考文献 编辑
- ^ Ashida, Hitoshi; Hashimoto, Takashi. Cell cycle inhibitors containing Brassicaceae isothiocyanates, and topical preparations, cosmetics, and health foods containing them. 2006 JP 2006089394 A.
- ^ Jun Yoshida, Satomi Nomura, Naoyuki Nishizawa, Yoshiaki Ito, Ken-ichi Kimura. Glycogen Synthase Kinase-3β Inhibition of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi ( Wasabia japonica Matsum). Bioscience, Biotechnology, and Biochemistry. 2011-01-23, 75 (1): 136–139 [2022-02-26]. ISSN 0916-8451. doi:10.1271/bbb.100507 （英语）.
- ^ Yoko Fuke, Yoshiko Haga, Haruhiro Ono, Takahiro Nomura, Kazuo Ryoyama. Anti-carcinogenic activity of 6-methylsulfinylhexyl isothiocyanate-, an active anti-proliferative principal of wasabi (Eutrema wasabi Maxim.). Cytotechnology. 1997-11-01, 25 (1): 197 [2022-02-26]. ISSN 1573-0778. PMC 3466737
. PMID 22358892. doi:10.1023/A:1007918508115 （英语）.
