2-氨基-5-甲氧基茚满

**2-氨基-5-甲氧基茚满**
臨床資料
商品名（英语：Drug nomenclature）	none
其他名稱	5-MeO-AI; 2,3-Dihydro-5-methoxy-1H-Inden-2-amine
给药途径	Oral
法律規範狀態
法律規範	德：NpSG; 英：PSA; Unscheduled;
藥物動力學數據
生物利用度	high
药物代谢	acetyl-aminoindandane
生物半衰期	non-linear
排泄途徑	full
识别信息
	IUPAC命名法 5-Methoxy-2-aminoindane; ;
CAS号	73305-09-6
PubChem CID	12147687;
ChemSpider	11591017;
UNII	AD8S15863A;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID80478566 ;
化学信息
化学式	C10H13NO
摩尔质量	163.22 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES COC1=CC2=C(CC(C2)N)C=C1;
	InChI InChI=1S/C10H13NO/c1-12-10-3-2-7-4-9(11)5-8(7)6-10/h2-3,6,9H,4-5,11H2,1H3; Key:HLXHCNWEVQNNKA-UHFFFAOYSA-N;

2-氨基-5-甲氧基茚满是一种有机化合物，化学式为C₁₀H₁₃NO。它是一种消遣性药物和预防酗酒的药物，最初于1998年在专利中以Markush结构被隐匿提及。^[1]它可以5-甲氧基茚满-2-酮^[2]或5-溴茚满-2-醇^[3]为原料制得。它和盐酸反应，可以得到2-氨基-5-甲氧基茚满盐酸盐。^[4]

参考文献编辑

^ US 5708018,Haadsma-Svensson, Susanne R.; Bengt R. Andersson & Clas A. Sonesson et al.,「2-aminoindans as selective dopamine D3 ligands」,发表于1998-01-13,指定于Pharmacia & Upjohn Co.
^ Renhowe, Paul A.; Chu, Daniel; Boyce, Rustum; Ni, Zhi-jie; Duhl, David; Tozzo, Effie; Johnson, Kirk; Myles, David. Preparation of guanidinobenzamides as melanocortin-4 receptor agonists useful for treating diseases such obesity and type II diabetes. 2002 WO 2002018327 A2.
^ Yusuf Akbaba, Süleyman Göksu, Ertan Şahin, Hamdullah Kılıç, Hasan Seçen. Synthesis and asymmetric resolution of a dopaminergic compound: 2-amino-5-methoxyindane. Tetrahedron: Asymmetry. 2016-07, 27 (11-12): 475–479 [2022-08-03]. doi:10.1016/j.tetasy.2016.04.005. （原始内容存档于2022-02-16）（英语）.
^ Chen, Xiaoli; Demarest, Keith T.; Lee, Jung; Matthews, Jay M.; Rybczynski, Philip. Preparation of substituted indanes and tetralins as PPARα modulators for treating Syndrome X. 2006 US 20060094786 A1.

[1] US 5708018,Haadsma-Svensson, Susanne R.; Bengt R. Andersson & Clas A. Sonesson et al.,「2-aminoindans as selective dopamine D3 ligands」,发表于1998-01-13,指定于Pharmacia & Upjohn Co.

[2] Renhowe, Paul A.; Chu, Daniel; Boyce, Rustum; Ni, Zhi-jie; Duhl, David; Tozzo, Effie; Johnson, Kirk; Myles, David. Preparation of guanidinobenzamides as melanocortin-4 receptor agonists useful for treating diseases such obesity and type II diabetes. 2002 WO 2002018327 A2.

[3] Yusuf Akbaba, Süleyman Göksu, Ertan Şahin, Hamdullah Kılıç, Hasan Seçen. Synthesis and asymmetric resolution of a dopaminergic compound: 2-amino-5-methoxyindane. Tetrahedron: Asymmetry. 2016-07, 27 (11-12): 475–479 [2022-08-03]. doi:10.1016/j.tetasy.2016.04.005. （原始内容存档于2022-02-16）（英语）.

[4] Chen, Xiaoli; Demarest, Keith T.; Lee, Jung; Matthews, Jay M.; Rybczynski, Philip. Preparation of substituted indanes and tetralins as PPARα modulators for treating Syndrome X. 2006 US 20060094786 A1.

[1]

[2]

[3]

[4]

2-氨基-5-甲氧基茚满

参考文献 编辑

参考文献编辑