A20細胞

A20 (亦稱ATCC TIB-208) 是於1979年在BALB/c小鼠發現的B細胞淋巴瘤細胞系[1],該球狀淋巴母細胞英语Lymphoblast表面光滑且中心部分較暗邊緣明顯,較常應用於存在免疫缺陷及具有免疫功能的動物模型構建[2][3],以進行疫苗靶點的選擇、研究抗腫瘤免疫機制和篩選藥物[4][5][6],由A20細胞所建立的模型的病理學特徵與人類瀰漫大B細胞淋巴瘤非常類似。

參考資料编辑

  1. ^ Kim, KJ; Kanellopoulos-Langevin, C; Merwin, RM; Sachs, DH; Asofsky, R. Establishment and characterization of BALB/c lymphoma lines with B cell properties.. Journal of immunology (Baltimore, Md. : 1950). 1979-02, 122 (2): 549–554 [2019-12-05]. PMID 310843. 
  2. ^ Küppers, R; Hansmann, ML. The Hodgkin and Reed/Sternberg cell.. The international journal of biochemistry & cell biology. 2005-03, 37 (3): 511–517 [2019-12-05]. PMID 15618006. doi:10.1016/j.biocel.2003.10.025. 
  3. ^ Yanagisawa, Y; Sato, Y; Asahi-Ozaki, Y; Ito, E; Honma, R; Imai, J; Kanno, T; Kano, M; Akiyama, H; Sata, T; Shinkai-Ouchi, F; Yamakawa, Y; Watanabe, S; Katano, H. Effusion and solid lymphomas have distinctive gene and protein expression profiles in an animal model of primary effusion lymphoma.. The Journal of pathology. 2006-2008, 209 (4): 464–73 [2019-12-05]. PMID 16741895. doi:10.1002/path.2012. 
  4. ^ Meziane el, K; Bhattacharyya, T; Armstrong, AC; Qian, C; Hawkins, RE; Stern, PL; Dermime, S. Use of adenoviruses encoding CD40L or IL-2 against B cell lymphoma.. International journal of cancer. 2004-10-10, 111 (6): 910–920 [2019-12-05]. PMID 15300803. doi:10.1002/ijc.20332. 
  5. ^ Siegel, S; Wagner, A; Kabelitz, D; Marget, M; Coggin J, Jr; Barsoum, A; Rohrer, J; Schmitz, N; Zeis, M. Induction of cytotoxic T-cell responses against the oncofetal antigen-immature laminin receptor for the treatment of hematologic malignancies.. Blood. 2003-12-15, 102 (13): 4416–23 [2019-12-05]. PMID 12869512. doi:10.1182/blood-2003-01-0198. 
  6. ^ Siegel, S; Wagner, A; Schmitz, N; Zeis, M. Induction of antitumour immunity using survivin peptide-pulsed dendritic cells in a murine lymphoma model.. British journal of haematology. 2003-09, 122 (6): 911–4 [2019-12-05]. PMID 12956760. doi:10.1046/j.1365-2141.2003.04535.x. 

外部連結编辑