APINACA

**APINACA**
法律規範狀態
法律規範	Temporary Class Drug (NZ), illegal in Japan;
识别信息
	IUPAC命名法 1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-1H-indazole-3-carboxamide; ;
CAS号	1345973-53-6
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID90928683 ;
化学信息
化学式	C23H31N3O
摩尔质量	365.510 g/mol
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C3C4CC2CC3CC(C4)(C2)NC(=O)c(nn1CCCCC)c5c1cccc5;

AKB48（APINACA, N-(1-金刚烷)-1-戊基-1H-吲唑-3-甲酰胺）是一种潜在的大麻素受体激动剂。此前它从未在科学界或专利文献中被报道过，2012年3月在日本的实验室中作为合成大麻混合烟的原料被识别出来^[1]。结构上它类似于专利号为WO 2003/035005（页面存档备份，存于互联网档案馆）的大麻素化合物，除了吲唑1位上引入了一条戊烷基链，因而APINACA应属于该专利所涵盖的范围，尽管尚未作为实例得到确认。APINACA于2012年在日本被宣布为非法药物^[2]，从2012年7月13日起作为临时类毒品在新西兰被禁止。^[3]

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^ Uchiyama, Nahoko; Kawamura, Maiko; Kikura-Hanajiri, Ruri; Goda, Yukihiro. Identification of two new-type synthetic cannabinoids, N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA), and detection of five synthetic cannabinoids, AM-1220, AM-2233, AM-1241, CB-13 (CRA-13), and AM-1248, as designer drugs in illegal products. Forensic Toxicology. 2012-04-10, 30 (2): 114–125. doi:10.1007/s11419-012-0136-7.
^ Designation of “Shitei Yakubutsu” (designated substances) based on the provision of the Pharmaceutical Affairs Law (1960, Law No.145) (PDF). [2012-07-17]. （原始内容存档 (PDF)于2019-02-15）.
^ Temporary Class Drug Notice, 05 July 2012. NZ Department of Internal Affairs.. [2012-07-17]. （原始内容存档于2013-06-15）.

[1] Uchiyama, Nahoko; Kawamura, Maiko; Kikura-Hanajiri, Ruri; Goda, Yukihiro. Identification of two new-type synthetic cannabinoids, N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA), and detection of five synthetic cannabinoids, AM-1220, AM-2233, AM-1241, CB-13 (CRA-13), and AM-1248, as designer drugs in illegal products. Forensic Toxicology. 2012-04-10, 30 (2): 114–125. doi:10.1007/s11419-012-0136-7.

[2] Designation of “Shitei Yakubutsu” (designated substances) based on the provision of the Pharmaceutical Affairs Law (1960, Law No.145) (PDF). [2012-07-17]. （原始内容存档 (PDF)于2019-02-15）.

[3] Temporary Class Drug Notice, 05 July 2012. NZ Department of Internal Affairs.. [2012-07-17]. （原始内容存档于2013-06-15）.

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APINACA

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