EGR4
位於2號人類染色體的基因
早期生长反应蛋白4（英語：Early growth response protein 4，EGR-4），也被称为AT133，是一个由人类基因EGR4编码的蛋白质[1]。
| 早期生长应答蛋白4 Early growth response 4 | |||
|---|---|---|---|
| 标识 | |||
| 代号 | EGR4; NGFI-C; NGFIC; PAT133 | ||
| 扩展标识 | 遗传学：128992 鼠基因：99252 同源基因：1485 GeneCards: EGR4 Gene | ||
| 直系同源体 | |||
| 物种 | 人类 | 小鼠 | |
| Entrez | 1961 | 13656 | |
| Ensembl | ENSG00000135625 | ENSMUSG00000071341 | |
| UniProt | Q05215 | Q9WUF2 | |
| mRNA序列 | NM_001965 | NM_020596 | |
| 蛋白序列 | NP_001956 | NP_065621 | |
| 基因位置 |
Chr 2: 73.52 – 73.52 Mb |
Chr 6: 85.51 – 85.51 Mb | |
| PubMed查询 | [1] | [2] | |
参考文献编辑
延伸阅读编辑
- Crosby SD, Veile RA, Donis-Keller H; 等. Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C.. Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (10): 4739–43. PMID 1584812. doi:10.1073/pnas.89.10.4739.
- Hillier LW, Graves TA, Fulton RS; 等. Generation and annotation of the DNA sequences of human chromosomes 2 and 4.. Nature. 2005, 434 (7034): 724–31. PMID 15815621. doi:10.1038/nature03466.
- Müller HJ, Skerka C, Bialonski A, Zipfel PF. Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains. Proc. Natl. Acad. Sci. U.S.A. November 1991, 88 (22): 10079–83. PMC 52871. PMID 1658795. doi:10.1073/pnas.88.22.10079.
- Decker EL, Nehmann N, Kampen E; 等. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression.. Nucleic Acids Res. 2003, 31 (3): 911–21. PMC 149206. PMID 12560487. doi:10.1093/nar/gkg186.
- Liu BC, Zhang J, Wang L; 等. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population.. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2010, 34 (3): 506–9. PMID 20144677. doi:10.1016/j.pnpbp.2010.02.005.
- Kimura K, Wakamatsu A, Suzuki Y; 等. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome Res. 2006, 16 (1): 55–65. PMC 1356129. PMID 16344560. doi:10.1101/gr.4039406.
- Holst C, Skerka C, Lichter P; 等. Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133.. Hum. Mol. Genet. 1993, 2 (4): 367–72. PMID 8504297. doi:10.1093/hmg/2.4.367.
- Crosby SD, Puetz JJ, Simburger KS; 等. The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family.. Mol. Cell. Biol. 1991, 11 (8): 3835–41. PMC 361165. PMID 2072895.
- Hadziselimovic F, Hadziselimovic NO, Demougin P; 等. EGR4 is a master gene responsible for fertility in cryptorchidism.. Sex Dev. 2009, 3 (5): 253–63. PMID 19828938. doi:10.1159/000249147.