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甲磺酸赖氨酸安非他命

(重定向自Lisdexamfetamine
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提示:本条目的主题不是左旋安非他命右旋安非他命安非他命

甲磺酸赖氨酸安非他命英语:Lisdexamfetamine),名字来源为“離胺酸-右旋安非他命”,是 中樞神經系統(CNS)右旋安非他命刺激剂前体药物,一种安非他命类英语substituted amphetamine苯乙胺英语substituted phenethylamine,用于治疗注意力不足過動症(ADHD)和過胖暴食症[4][5]

甲磺酸赖氨酸安非他命
Lisdexamfetamine structure.svg
Lisdexamfetamine ball-and-stick model.png
系统(IUPAC)命名名称
(2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide
临床数据
Drugs.com Monograph
MedlinePlus a607047
医疗法规
妊娠分级
  • AU: B3
  • US: C (不排除有风险的可能)
依赖性 身体依赖: 无
精神依赖: 中等
成瘾性 中等
给药途径 口服(胶囊
合法狀態
合法状态
药代动力学数据
生物利用度 96.4%[1]
代谢 起初由红血球水解
余下的代谢过程同安非他命#药物代谢动力学
起效 2小时[2][3]
生物半衰期 ≤1小时(前体药物分子)
9至11小时(右旋安非他命)
作用时间 12 hours[2][3]
排泄 肾脏:约2%
识别信息
CAS注册号 608137-32-2 ✓[IUPHAR]
ATC代码 N06BA12
PubChem CID 11597698
IUPHAR/BPS英语IUPHAR/BPS 7213
DrugBank DB01255 ✓
ChemSpider 9772458 ✓[Chemspider]
UNII H645GUL8KJ ✓
ChEMBL英语ChEMBL CHEMBL1201222 ✓
其他名称 Vyvanse
化学信息
化学式 C15H25N3O
摩尔质量 263.378 g/mol
 ✗✓ (what is this?)英语Wikipedia:WikiProject_Chemicals/Chembox_validation  (verify)
30毫克Vyvanse胶囊

参考资料编辑

  1. ^ Public Assessment Report Decentralised Procedure (PDF). Shire Pharmaceuticals Contracts Limited: 14. [2014-08-23]. 
  2. ^ 2.0 2.1 Millichap JG. Chapter 9: Medications for ADHD. (编) Millichap JG. Attention Deficit Hyperactivity Disorder Handbook: A Physician's Guide to ADHD 2nd. New York, USA: Springer. 2010: 112. ISBN 9781441913968.
    Table 9.2 Dextroamphetamine formulations of stimulant medication
    Dexedrine [Peak:2–3 h] [Duration:5–6 h] ...
    Adderall [Peak:2–3 h] [Duration:5–7 h]
    Dexedrine spansules [Peak:7–8 h] [Duration:12 h] ...
    Adderall XR [Peak:7–8 h] [Duration:12 h]
    Vyvanse [Peak:3–4 h] [Duration:12 h]
     
  3. ^ 3.0 3.1 Brams M, Mao AR, Doyle RL. Onset of efficacy of long-acting psychostimulants in pediatric attention-deficit/hyperactivity disorder. Postgrad. Med. September 2008, 120 (3): 69–88. PMID 18824827. doi:10.3810/pgm.2008.09.1909. Onset of efficacy was earliest for d-MPH-ER at 0.5 hours, followed by d, l-MPH-LA at 1 to 2 hours, MCD at 1.5 hours, d, l-MPH-OR at 1 to 2 hours, MAS-XR at 1.5 to 2 hours, MTS at 2 hours, and LDX at approximately 2 hours. ... MAS-XR, and LDX have a long duration of action at 12 hours postdose 
  4. ^ Vyvanse Prescribing Information (PDF). United States Food and Drug Administration. Shire US Inc. January 2015 [2015-02-24]. 
  5. ^ Heal DJ, Smith SL, Gosden J, Nutt DJ. Amphetamine, past and present – a pharmacological and clinical perspective. J. Psychopharmacol. June 2013, 27 (6): 479–496. PMC 3666194. PMID 23539642. doi:10.1177/0269881113482532.