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MASP-1

位於3號人類染色體的基因

甘露糖结合凝集素丝氨酸蛋白酶1 (Mannan-binding lectin serine protease 1,也被称为 甘露糖相关丝氨酸蛋白酶1,mannose-associated serine protease 1,缩写MASP-1)是由人类基因 MASP1 编码的一种[1][2][3]

Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 MASP1; 3MC1; CRARF; CRARF1; MAP1; MASP; MASP3; MAp44; PRSS5; RaRF
扩展标识 遗传学600521 同源基因89143 GeneCards: MASP1 Gene
EC編號 3.4.21.-
直系同源体
物种 人类 小鼠
Entrez 5648 n/a
Ensembl ENSG00000127241 n/a
UniProt P48740 n/a
mRNA序列 NM_001031849 n/a
蛋白序列 NP_001027019 n/a
基因位置 Chr 3:
187.22 – 187.29 Mb
n/a
PubMed查询 [1] n/a

MASP-1参与补体系统的凝集素途径,负责的切割C4C2形成C4b2a,作为C3-转化酶参与下一步的反应。[4]

另见编辑

参考文献编辑

  1. ^ A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum. Biochemical and Biophysical Research Communications. Oct 1993, 196 (2): 1003–9. PMID 8240317. doi:10.1006/bbrc.1993.2349. 
  2. ^ Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein. International Immunology. Apr 1994, 6 (4): 665–9. PMID 8018603. doi:10.1093/intimm/6.4.665. 
  3. ^ Entrez Gene: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor). 
  4. ^ Proteolytic activities of two types of mannose-binding lectin-associated serine protease. Journal of Immunology. Sep 2000, 165 (5): 2637–42. PMID 10946292. doi:10.4049/jimmunol.165.5.2637. 

外部链接编辑

MASP-1引用了美国国家医学图书馆提供的資料,这些資料属于公共领域