S100蛋白

蛋白质家族

S100蛋白(英語:S100 proteins)是一种脊椎动物的低分子量蛋白质家族,具有两个碱性螺旋-环-螺旋结合位点(EF手型)。已知有21种不同的S100蛋白[1]。编码这些蛋白的基因家族的基因以S100为前缀,如S100A1, S100A2, S100A3等。 这一家族的蛋白也被视为是损伤相关分子模式(Damage-associated molecular pattern,DAMP)的分子。

S100/ICaBP type calcium binding domain
Protein S100B PDB 1b4c.png
Structure of the S100B protein. Based on PyMOL rendering of PDB 1b4c.
鑑定
標誌S_100
PfamPF01023
InterPro英语InterProIPR013787
PROSITE英语PROSITEPDOC00275
 SCOP英语Structural Classification of Proteins1cnp / SUPFAM

相关的人类基因编辑


参考文献编辑

  1. ^ Marenholz I, Heizmann CW, Fritz G. S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). Biochem. Biophys. Res. Commun. October 2004, 322 (4): 1111–22. PMID 15336958. doi:10.1016/j.bbrc.2004.07.096. 
  2. ^ Penumutchu, Srinivasa R.; Chou, Ruey-Hwang; Yu, Chin. Structural Insights into Calcium-Bound S100P and the V Domain of the RAGE Complex. PLOS ONE. 2014-08-01, 9 (8): e103947 [2020-09-26]. ISSN 1932-6203. PMC 4118983 . PMID 25084534. doi:10.1371/journal.pone.0103947. (原始内容存档于2017-01-12). 
  3. ^ Penumutchu, Srinivasa R.; Chou, Ruey-Hwang; Yu, Chin. Interaction between S100P and the anti-allergy drug cromolyn. Biochemical and Biophysical Research Communications. 2014-10-17, 454 (3): 404–409. ISSN 1090-2104. PMID 25450399. doi:10.1016/j.bbrc.2014.10.048. 

延伸阅读编辑

  • Wolf R, Voscopoulos CJ, FitzGerald PC, et al. The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation. J. Invest. Dermatol. 2006, 126 (7): 1600–8. PMID 16528363. doi:10.1038/sj.jid.5700210. 
  • Ronald Wolf, O. M. Zack Howard, Hui-Fang Dong, Christopher Voscopoulos, Karen Boeshans, Jason Winston, Rao Divi, Michele Gunsior, Paul Goldsmith, Bijan Ahvazi, Triantafyllos Chavakis, Joost J. Oppenheim and Stuart H. Yuspa. Chemotactic Activity of S100A7 (Psoriasin) Is Mediated by the Receptor for Advanced Glycation End Products and Potentiates Inflammation with Highly Homologous but Functionally Distinct S100A15.. The Journal of Immunology. 2010, 181 (2): 1499–1506. 
  • Ronald Wolf, Francesca Mascia, Alif Dharamsi, O. M. Zack Howard, Christophe Cataisson, Val Bliskovski, Jason Winston, Lionel Feigenbaum, Ulrike Lichti, Thomas Ruzicka Triantafyllos Chavakis, and Stuart H. Yuspa. Gene from a Psoriasis Susceptibility Locus Primes the Skin for Inflammation.. Science Translational Medicine. 2010, 2 (61): 61ra90. PMID 21148126. doi:10.1126/scitranslmed.3001108. 

外部链接编辑

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