苹果酸脱氢酶 (草酰乙酸脱羧) (NADP+)

蘋果酸脫氫酶 (草酰乙酸脫羧) (NADP⁺)（英語：malate dehydrogenase (oxaloacetate-decarboxylating) (NADP⁺)，EC 1.1.1.40 （頁面存檔備份，存於互聯網檔案館））是一種以NAD⁺或NADP⁺為受體、作用於供體CH-OH基團上的氧化還原酶。這種酶能催化以下酶促反應：

蘋果酸脫氫酶 (草酰乙酸脫羧) (NADP+)
蘋果酸脫氫酶 (草酰乙酸脫羧) (NADP+)的結構（PDB 2AW5）
命名 系統命名 (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating) 縮寫 別名 'malic' enzyme; pyruvic-malic carboxylase; malate dehydrogenase (decarboxylating, NADP); NADP-linked decarboxylating malic enzyme; NADP-malic enzyme; NADP-specific malic enzyme; NADP-specific malate dehydrogenase; malate dehydrogenase (NADP, decarboxylating); L-malate:NADP oxidoreductase; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP)
識別碼
EC編號	1.1.1.40
CAS號	9028-47-1
數據庫
IntEnz	IntEnz瀏覽
BRENDA	BRENDA入口
ExPASy	NiceZyme瀏覽
KEGG	KEGG入口
MetaCyc	代謝路徑
PRIAM	概述
PDB	RCSB PDB PDBj PDBe PDBsum
基因本體	AmiGO / EGO
搜索 PMC 相關文獻 PubMed 相關文獻

(S)-蘋果酸 + NADP⁺ $\rightleftharpoons$ 丙酮酸 + CO₂ + NADPH

蘋果酸脫氫酶 (草酰乙酸脫羧) (NADP⁺)是C₄和CAM植物固定二氧化碳過程中使用的三種脫羧酶之一（其餘兩種分別為蘋果酸脫氫酶 (脫羧)和磷酸烯醇丙酮酸羧化激酶）。

參考文獻

• Harary, I., Korey, S.R. and Ochoa, S. Biosynthesis of dicarboxylic acids by carbon dioxide fixation. VII Equilibrium of malic enzyme reaction. J. Biol. Chem. 1953, 203 (2): 595–604. PMID 13084629. 
• Ochoa S, Mehler AH and Kornberg A. Biosynthesis of dicarboxylic acids by carbon dioxide fixation. I Isolation and properties of an enzyme from pigeon liver catalyzing the reversible oxidative decarboxylation of l-malic acid. J. Biol. Chem. 1948, 174: 979–1000. 
• RUTTER WJ, LARDY HA. Purification and properties of pigeon liver malic enzyme. J. Biol. Chem. 1958, 233 (2): 374–82. PMID 13563505. 
• Strickland RG. Some properties of the malic enzyme of pigeon liver. 1. Conversion of malate into pyruvate. Biochem. J. 1959, 73: 646–654. 
• Strickland RG. Some properties of the malic enzyme of pigeon liver. 2. Synthesis of malate from pyruvate. Biochem. J. 1959, 73: 654–659. PMC 1197116 . PMID 13834657. 
• Walker DA. Physiological studies on acid metabolism. 7. Malic enzyme from Kalanchoe crenata: effects of carbon dioxide concentration. Biochem. J. 1960, 74: 216–223. PMC 1204145 . PMID 13842495.