6-羥基黃酮

化合物

6-羥基黃酮(英語:6-Hydroxyflavone)是一種黃酮類化合物,是細胞色素P450CYP2C9非競爭性抑制英語Non-competitive inhibition劑。6-羥基黃酮可在黃花假杜鵑(學名:Barleria prionitis)的葉子中發現[3], 有可能成為治療焦慮樣障礙的潛在藥物[4][5]

6-Hydroxyflavone
Ball-and-stick model of 6-hydroxyflavone
IUPAC名
6-hydroxy-2-phenylchromen-4-one
別名 6-Monohydroxyflavone; 6-Hydroxy-2-phenyl-4-benzopyrone
識別
CAS號 6665-83-4  checkY
PubChem 72279
ChemSpider 65233
SMILES
 
  • C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=CC(=C3)O
InChI
 
  • 1/C15H10O3/c16-11-6-7-14-12(8-11)13(17)9-15(18-14)10-4-2-1-3-5-10/h1-9,16H
InChIKey GPZYYYGYCRFPBU-UHFFFAOYAV
KEGG C14137
性質
化學式 C15H10O3
摩爾質量 238.24 g·mol−1
密度 1.411 g·cm−3[1]
熔點 235.5—236.5 °C(508.6—509.6 K)[2]
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。


參考文獻

編輯
  1. ^ J. Seetharaman, S. S. Rajan. Structure of 6-hydroxyflavone. Acta Crystallographica Section C Crystal Structure Communications. 1992-09-15, 48 (9): 1714–1715 [2021-01-08]. doi:10.1107/S0108270192005456. (原始內容存檔於2018-06-02). 
  2. ^ J. H. Looker, Walter W. Hanneman. Physical and Chemical Properties of Hydroxyflavones. I. Infrared Absorption Spectra of Monohydroxyflavones and Their O-Methyl and O-Acetyl Derivatives 1,2. The Journal of Organic Chemistry. 1962-02, 27 (2): 381–389 [2021-01-08]. ISSN 0022-3263. doi:10.1021/jo01049a010 (英語). 
  3. ^ M Daniel. Medicinal Plants: Chemistry and Properties. Science Publishers. 2006: 78 [2021-01-08]. ISBN 978-1-57808-395-4. (原始內容存檔於2022-03-09). 
  4. ^ Ren, Lihuan; Wang, Feng; Xu, Zhiwen; Chan, Wing Man; Zhao, Cunyou; Xue, Hong, GABAA receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone, Biochemical Pharmacology, 2010, 79 (9): 1337–1344, PMID 20067772, doi:10.1016/j.bcp.2009.12.024 
  5. ^ 6-HYDROXYFLAVONE | CAS:6665-83-4 | Huateng Pharma | Pharmaceutical chemical reagents, PEG derivatives. en.huatengsci.com. [2020-03-27]. (原始內容存檔於2021-01-10). 

外部連結

編輯
  • 6-hydroxy flavone on Plant Metabolic Network