奎孕酮

化合物

奎孕酮(英语:Quingestrone)也称为孕酮-3-烯醇环戊醚(progesterone 3-cyclopentyl enol ether,PCPE)是一种黄体制剂药物,在1962年起用作复合口服避孕药,但在意大利等国已不再使用[1][2][3][4][5]

奎孕酮
临床资料
商品名英语Drug nomenclatureEnol-Luteovis
其他名称W-3399; Progesterone 3-cyclopentyl enol ether; PCPE; 3-Cyclopentyloxypregna-3,5-dien-20-one
给药途径By mouth
药物类别英语Drug classProgestin; Progestogen; Progestogen ether; Neurosteroid
ATC码
法律规范状态
法律规范
  • 处方药(-only)
识别信息
  • 1-[(8S,9S,10R,13S,14S,17S)-3-cyclopentyloxy-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
CAS号67-95-8
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C26H38O2
摩尔质量382.579 g/mol
3D模型(JSmol英语JSmol
  • CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(=C4)OC5CCCC5)C)C
  • InChI=1S/C26H38O2/c1-17(27)22-10-11-23-21-9-8-18-16-20(28-19-6-4-5-7-19)12-14-25(18,2)24(21)13-15-26(22,23)3/h8,16,19,21-24H,4-7,9-15H2,1-3H3/t21-,22+,23-,24-,25-,26+/m0/s1
  • Key:XAVRSHOUEXATJE-FBQZJRKBSA-N

奎孕酮作为一种黄体制剂(人工合成的孕激素),能作为孕酮生物学靶点——孕酮受体激动剂[1],另外也具有较弱的糖皮质激素活性。


参考文献

编辑
  1. ^ 1.0 1.1 J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 1058 [2019-02-26]. ISBN 978-1-4757-2085-3. OCLC 898564124. doi:10.1007/978-1-4757-2085-3. (原始内容存档于2021-01-26). 
  2. ^ International Planned Parenthood Federation. Medical Committee. Oral Advisory Group. Handbook on oral contraception. Little, Brown. 1965: 18 [2019-02-26]. OCLC 2717593. (原始内容存档于2021-01-07). 
  3. ^ Larrey D, Geneve J, Pessayre D, Machayekhi JP, Degott C, Benhamou JP. Prolonged cholestasis after cyproheptadine-induced acute hepatitis. J. Clin. Gastroenterol. 1987, 9 (1): 102–4. ISSN 0192-0790. PMID 3559100. doi:10.1097/00004836-198702000-00026. She had been taking an oral contraceptive combining ethinylestradiol and quingestrone since 1980. 
  4. ^ Denis Frank Hawkins. Obstetric therapeutics: clinical pharmacology and therapeutics in obstetric practice. Baillière Tindall. 1974: 129, 138, 145 [2019-02-26]. ISBN 978-0-7020-0471-1. (原始内容存档于2020-08-19). 
  5. ^ P. J. Bentley. Endocrine Pharmacology: Physiological Basis and Therapeutic Applications. CUP Archive. 1980: 274– [2019-02-26]. ISBN 978-0-521-22673-8. (原始内容存档于2020-08-20).