缺氧诱导因子脯胺酸羟化酶
HIF脯胺酸羟化酶（英语：HIF prolyl-hydroxylase）是一个包含在缺氧诱导因子（英语：Hypoxia-inducible factor，简称：HIF）讯息路径中的酶，也是一系列称为HIF脯胺酸羟化酶抑制剂 治疗性药物的目标
缺氧诱导因子(HIF)是一个在演化上被保留下来的转录因子[1]，它让细胞可以针对低氧浓度环境作出生理性的反应[2]。其中一种特定作用在HIF上的脯胺酸羟化酶已经被确认存在；[3]而羟基化的HIF能让蛋白质被作为降解的目标[3]
HIF脯胺酸羟化酶已经被各式各样抑制剂作为目标，用来治疗中风[4]，肾脏疾病[5]缺血[6]，贫血[7]，和其他重大疾病。在红血球过多症相关以及乳癌相关的PHD2突变的案例中，临床观察下的脯胺酸羟化酶区域突变会影响它对HIF受质的选择性，这点对药物设计有重要的意义[8] 。 在人体中，HIF脯胺酸双氧化酶有三种种型。分别是 PHD1、PHD2和PHD3。其中，PHD2因为它对氧气缓慢的反应速度而被视为人体最重要的氧气感应器[9]。
参考文献 编辑
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