可溶性N-乙基马来酰亚胺敏感性因子附着蛋白受体(英语:SNAP REceptor,即SNAP受体,又称可溶性NSF附着蛋白受体),又称SNARE蛋白,是一个大的蛋白质家族,由酵母菌中的至少24个成员和哺乳动物细胞中的60个以上的成员组成。[2][3]SNARE蛋白的主要作用是介导囊泡融合以及囊泡靶膜的融合。这尤其介导胞吐作用,但也可以介导囊泡与膜结合区室(如溶酶体)的融合。研究最深入的SNARE是介导神经元突触小泡神经递质释放。这些神经元SNAREs是负责某些细菌产生的肉毒杆菌中毒和破伤风的等神经毒素的标靶。

Molecular machinery driving vesicle fusion in neuromediator release. The core SNARE complex is formed by four α-helices contributed by synaptobrevin, syntaxin and SNAP-25, synaptotagmin serves as a calcium sensor and closely regulates the SNARE zipping.[1]
SNARE-fusion membrane complex proteins
鉴定
标志SNARE
InterPro英语InterProIPR010989
SCOP英语Structural Classification of Proteins1kil / SUPFAM
TCDB英语TCDB1.F.1
OPM英语Orientations of Proteins in Membranes database家族197
OPM英语Orientations of Proteins in Membranes database蛋白3hd7
膜蛋白数据库英语Membranome198

参考资料

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  1. ^ Georgiev, Danko D; James F . Glazebrook. Subneuronal processing of information by solitary waves and stochastic processes. Lyshevski, Sergey Edward (编). Nano and Molecular Electronics Handbook. Nano and Microengineering Series. CRC Press. 2007: 17–1–17–41 [2020-10-09]. ISBN 978-0-8493-8528-5. doi:10.1201/9781420008142.ch17 (不活跃 2020-09-09). (原始内容存档于2016-01-16). 
  2. ^ Burri, Lena; Lithgow, Trevor. A complete set of SNAREs in yeast. Traffic. 2004-01-01, 5 (1): 45–52. ISSN 1398-9219. PMID 14675424. doi:10.1046/j.1600-0854.2003.00151.x. 
  3. ^ Gerald K. Cell and Molecular Biology 4th. John Wiley & Sons. 2002. 

外部链接

编辑