5-羥色胺和去甲腎上腺素再攝取抑制劑

5-羥色胺和去甲腎上腺素再攝取抑制劑(英語:SNRIs, Serotonin–norepinephrine reuptake inhibitors),是一種用來治療重度抑鬱症和其他精神障礙抗抑鬱藥。SNRI有時候也用來治療焦慮症強迫症多動症,慢性神經性疼痛,軀體化障礙,纖維肌痛症候群和緩解更年期症狀。

SNRI是高效的5-羥色胺去甲腎上腺素再攝取抑制劑。[1]已知這些神經遞質在控制情緒時發揮著重要的作用。 SNRI比使用更廣泛但只能單獨作用於5-羥色胺的選擇性5-羥色胺再攝取抑制劑(SSRI)作用更多。

Timeline-SNRIs-2010
已批准的SNRI時間線圖
活性成分 藥品名稱 治療用途 受體親和力
(Ki, nm)
結構
文拉法辛(Venlafaxine) 怡諾思(Efexor) 重性抑鬱障礙,包括對其他治療沒反應的患者,廣泛性焦慮症慢性疼痛綜合症[2] 5-HT:7.8
NE:1920
D:6050 [3]
米那普侖(Milnacipran) Savella, Ixel, Dalcipran, Toledomin 纖維肌痛症候群及其併發症,重度抑鬱障礙[4] 5-HT:8.4
NE:22
D:>100000[3]
Milnacipran
Milnacipran
度洛西汀(Duloxetine) Cymbalta, Ariclaim, Xeristar, Yentreve 重度抑鬱障礙和纖維肌痛症候群[5] 5-HT:0.07
NE:1.2
D:230[3]
Duloxetine
Duloxetine
左旋米那普倫 Fetzima 成人重度抑鬱障礙 5-HT:NA
NE:NA
D:NA
Levomilnacipran
Levomilnacipran
去甲文拉法辛(Desvenlafaxine) Pristiq 成人重度抑鬱障礙[6] 5-HT:61.4
NE:2953
D:NA
西布曲明(Sibutramine) Meridia, Reductil 肥胖[7] 5-HT:298
NE:5451
D:943

5-HT: 5-羥色胺- NE: 去甲腎上腺素- D: 多巴胺- NA: 不可用

引用

編輯
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