MYO5A是一个位于人类15号染色体上的基因,编码一种隶属肌凝蛋白超家族的非典型的肌凝蛋白肌凝蛋白-Va(Myosin-Ia)。肌凝蛋白-Va与细胞内囊泡细胞器,以及蛋白复合体通过微丝纤维运输有关[5][6][7][8][9][10]

MYO5A
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名MYO5A;, GS1, MYH12, MYO5, MYR12, myosin VA
外部IDOMIM160777 MGI105976 HomoloGene20100 GeneCardsMYO5A
基因位置(人类
15號染色體
染色体15號染色體[1]
15號染色體
MYO5A的基因位置
MYO5A的基因位置
基因座15q21.2起始52,307,281 bp[1]
终止52,529,132 bp[1]
RNA表达模式
查阅更多表达数据
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

​NM_000259
​NM_001142495
​NM_001382347
​NM_001382348
​NM_001382349

NM_010864

蛋白序列

NP_000250
​NP_001135967
​NP_001369276
​NP_001369277
​NP_001369278

NP_034994

基因位置​(UCSC)Chr 15: 52.31 – 52.53 MbChr 9: 74.98 – 75.13 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

参见

编辑

参考资料

编辑
  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000197535 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000034593 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Velvarska, Hana; Niessing, Dierk. Structural Insights into the Globular Tails of the Human Type V Myosins Myo5a, Myo5b, and Myo5c. PLOS ONE. 2013-12-10, 8 (12): e82065. Bibcode:2013PLoSO...882065V. ISSN 1932-6203. PMC 3858360 . PMID 24339992. doi:10.1371/journal.pone.0082065. 
  6. ^ Wöllert, Torsten; Patel, Anamika; Lee, Ying-Lung; Provance, D. William; Vought, Valarie E.; Cosgrove, Michael S.; Mercer, John A.; Langford, George M. Myosin5a Tail Associates Directly with Rab3A-containing Compartments in Neurons. The Journal of Biological Chemistry. 2011-04-22, 286 (16): 14352–14361. ISSN 0021-9258. PMC 3077635 . PMID 21349835. doi:10.1074/jbc.M110.187286. 
  7. ^ Schumacher-Bass, Sarah M.; Vesely, Eileen D.; Zhang, Lian; Ryland, Katherine E.; McEwen, Dyke P.; Chan, Priscilla J.; Frasier, Chad R.; McIntyre, Jeremy C.; Shaw, Robin M.; Martens, Jeffrey R. A Role for Myosin V Motor Proteins in the Selective Delivery of Kv Channel Isoforms to the Membrane Surface of Cardiac Myocytes. Circulation Research. 2014-03-14, 114 (6): 982–992. ISSN 0009-7330. PMC 4213814 . PMID 24508725. doi:10.1161/CIRCRESAHA.114.302711. 
  8. ^ Engle LJ, Kennett RH. Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene. Genomics. Feb 1994, 19 (3): 407–16. PMID 8188282. doi:10.1006/geno.1994.1088. 
  9. ^ Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. Proceedings of the National Academy of Sciences of the United States of America. Jul 1994, 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. PMC 44240 . PMID 8022818. doi:10.1073/pnas.91.14.6549. 
  10. ^ Entrez Gene: MYO5A myosin VA (heavy chain 12, myoxin).