伏妥珠单抗
伏妥珠单抗(INN:flotetuzumab[1];开发代号:MGD006)是一种双特异性抗体,[2]设计用于治疗急性骨髓性白血病。[3][4]该药物由MacroGenics公司开发。[5]
单克隆抗体 | |
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种类 | 双单链可变区片段 |
目標 | CD3、CD123 |
臨床資料 | |
其他名稱 | MGD006 |
ATC碼 |
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识别信息 | |
CAS号 | 1664355-28-5 |
ChemSpider |
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UNII | |
KEGG | |
化学信息 | |
化学式 | C2618H4040N704O813S16 |
摩尔质量 | 58,898.19 g·mol−1 |
参考资料
编辑- ^ World Health Organization. International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 118 (PDF). WHO Drug Information. 2017, 31 (4) [2024-03-12]. (原始内容存档 (PDF)于2020-08-15).
- ^ Guy DG, Uy GL. Bispecific Antibodies for the Treatment of Acute Myeloid Leukemia. Curr Hematol Malig Rep. October 2018, 13 (6): 417–425. PMC 6295344 . PMID 30280288. doi:10.1007/s11899-018-0472-8.
- ^ Campagne O, Delmas A, Fouliard S, Chenel M, Chichili GR, Li H, Alderson R, Scherrmann JM, Mager DE. Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity. Clin. Cancer Res. June 2018, 24 (11): 2631–2641. PMID 29463552. doi:10.1158/1078-0432.CCR-17-2265 ..
- ^ Assi R, Kantarjian H, Ravandi F, Daver N. Immune therapies in acute myeloid leukemia: a focus on monoclonal antibodies and immune checkpoint inhibitors. Curr. Opin. Hematol. March 2018, 25 (2): 136–145. PMID 29206680. S2CID 23901088. doi:10.1097/MOH.0000000000000401.
- ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Flotetuzumab (页面存档备份,存于互联网档案馆), American Medical Association.