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肿瘤微环境英语:Tumor microenvironment)是指肿瘤细胞存在的周围微环境,包括周围的血管、免疫细胞、成纤维细胞、骨髓源性炎性细胞、各种信号分子和细胞外基质(ECM)。[1][2][3]

肿瘤和周围环境密切相关,不断进行交互作用,肿瘤可以通过释放细胞信号分子影响其微环境环境,促进肿瘤的血管生成和诱导免疫耐受,而微环境中的免疫细胞可影响癌细胞增长和发育。[4]

肿瘤微环境有助于肿瘤异质性英语Tumour heterogeneity的形成。

参考文献编辑

  1. ^ NCI Dictionary of Cancer Terms. National Cancer Institute. 
  2. ^ Joyce, Johanna A.; Fearon, Douglas T. T cell exclusion, immune privilege, and the tumor microenvironment. Science Magazine: 74–80. 3 April 2015 [2015-06-25]. doi:10.1126/science.aaa6204. 
  3. ^ Spill, F.; Reynolds, D.S.; Kamm, R.D.; Zaman, M.H. Impact of the physical microenvironment on tumor progression and metastasis. Current Opinion in Biotechnology: 41–48. doi:10.1016/j.copbio.2016.02.007. 
  4. ^ Korneev, KV; Atretkhany, KN; Drutskaya, MS; Grivennikov, SI; Kuprash, DV; Nedospasov, SA. TLR-signaling and proinflammatory cytokines as drivers of tumorigenesis.. Cytokine. January 2017, 89: 127–135. PMID 26854213. doi:10.1016/j.cyto.2016.01.021.