酮啡诺
化合物
酮啡诺(INN:ketorfanol;开发代号:SBW-22)是一种吗啡喃家族的阿片类镇痛药,在动物试验中被发现具有“有效的抗扭体活性”,但从未上市。[1][2]它是吗啡喃的17-环烷基甲基衍生物,因此在结构上与布托啡诺、赛克罗酚、奥昔啡烷、普罗啡烷和佐尔啡诺密切相关,它们优先充当κ-阿片受体激动剂,并在较小程度上充当μ-阿片受体部分激动剂/拮抗剂。[3]
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CAS号 | 79798-39-3 |
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化学信息 | |
化学式 | C20H25NO2 |
摩尔质量 | 311.43 g·mol−1 |
3D模型(JSmol) | |
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参考资料
编辑- ^ Elks J. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 2014-11-14: 720–. ISBN 978-1-4757-2085-3.
- ^ Korolkovas A. Essentials of Medicinal Chemistry. Wiley. 1988-08-16: 243. ISBN 978-0-471-88356-2.
- ^ Neumeyer JL, Bidlack JM, Zong R, Bakthavachalam V, Gao P, Cohen DJ, et al. Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence. Journal of Medicinal Chemistry. January 2000, 43 (1): 114–22. PMID 10633042. doi:10.1021/jm9903343.