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激素替代療法英语:Hormone replacement therapy, HRT)是一種荷爾蒙療法,用於治療女性更年期相關的症狀。[1][2]這些症狀可能包括潮熱,陰道萎縮和乾燥,以及骨質流失等,並且是由更年期期間性激素水平降低引起的。[3][4]激素替代療法用於更年期症狀的主要激素藥物是雌激素孕激素[5]對於擁有完整子宮女性孕激素通常與雌激素聯合使用,因為無對抗的雌激素治療與子宮內膜增生和癌症有關,而孕激素可預防這些風險。[5][6][7]睾酮這樣的雄激素有時也用於激素替代療法。[8]激素替代療法藥物有多種形式,可通過各種不同的給藥途徑使用。[5]

參考資料编辑

  1. ^ Stuenkel CA, Davis SR, Gompel A, Lumsden MA, Murad MH, Pinkerton JV, Santen RJ. Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. November 2015, 100 (11): 3975–4011. PMID 26444994. doi:10.1210/jc.2015-2236. 
  2. ^ Santen RJ, Allred DC, Ardoin SP, Archer DF, Boyd N, Braunstein GD, Burger HG, Colditz GA, Davis SR, Gambacciani M, Gower BA, Henderson VW, Jarjour WN, Karas RH, Kleerekoper M, Lobo RA, Manson JE, Marsden J, Martin KA, Martin L, Pinkerton JV, Rubinow DR, Teede H, Thiboutot DM, Utian WH. Postmenopausal hormone therapy: an Endocrine Society scientific statement. J. Clin. Endocrinol. Metab. July 2010, 95 (7 Suppl 1): s1–s66. PMID 20566620. doi:10.1210/jc.2009-2509. 
  3. ^ Stuenkel CA, Davis SR, Gompel A, Lumsden MA, Murad MH, Pinkerton JV, Santen RJ. Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. November 2015, 100 (11): 3975–4011. PMID 26444994. doi:10.1210/jc.2015-2236. 
  4. ^ Santen RJ, Allred DC, Ardoin SP, Archer DF, Boyd N, Braunstein GD, Burger HG, Colditz GA, Davis SR, Gambacciani M, Gower BA, Henderson VW, Jarjour WN, Karas RH, Kleerekoper M, Lobo RA, Manson JE, Marsden J, Martin KA, Martin L, Pinkerton JV, Rubinow DR, Teede H, Thiboutot DM, Utian WH. Postmenopausal hormone therapy: an Endocrine Society scientific statement. J. Clin. Endocrinol. Metab. July 2010, 95 (7 Suppl 1): s1–s66. PMID 20566620. doi:10.1210/jc.2009-2509. 
  5. ^ 5.0 5.1 5.2 Kuhl H. Pharmacology of estrogens and progestogens: influence of different routes of administration (PDF). Climacteric. 2005,. 8 Suppl 1: 3–63. PMID 16112947. doi:10.1080/13697130500148875. 
  6. ^ Shuster, Lynne T.; Rhodes, Deborah J.; Gostout, Bobbie S.; Grossardt, Brandon R.; Rocca, Walter A. Premature menopause or early menopause: Long-term health consequences. Maturitas. 2010, 65 (2): 161–166. ISSN 0378-5122. PMC 2815011. PMID 19733988. doi:10.1016/j.maturitas.2009.08.003. 
  7. ^ Eden, K.J., & Wylie, K.R. (2009). Quality of sexual life and menopause. Women’s Health, 5 (4), 385-396. doi:10.2217/whe.09.24
  8. ^ Ziaei, S., Moghasemi, M., & Faghihzadeh, S. (2010). Comparative effects of conventional hormone replacement therapy and tibolone on climacteric symptoms and sexual dysfunction in postmenopausal women. Climateric, 13, 147-156. doi:10.1016/j.maturitas.2006.04.014