PAS结构域

現有可用的蛋白結構：
Pfam	結構（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	結構概要
PDB	1byw, 1d06, 1d7e, 1dp6, 1dp8, 1dp9, 1drm, 1ew0, 1f98, 1f9i, 1gsv, 1gsw, 1gsx, 1kou, 1ll8, 1lsv, 1lsw, 1lsx, 1lt0, 1mzu, 1nwz, 1odv, 1ot6, 1ot9, 1ota, 1otb, 1otd, 1ote, 1oti, 1s1y, 1s1z, 1s4r, 1s4s, 1s66, 1s67, 1t18, 1t19, 1t1a, 1t1b, 1t1c, 1ts0, 1ts6, 1ts7, 1ts8, 1ugu, 1uwn, 1uwp, 1v9y, 1v9z, 1vb6, 1wa9, 1xfn, 1xfq, 1xj2, 1xj3, 1xj4, 1xj6, 1y28, 2d01, 2d02, 2phy, 2pyp, 2pyr, 3phy, 3pyp

PAS折叠
	细菌的氧气感受蛋白fixL的PAS结构域的晶体结构。蛋白以飘带图展示，其中N-末端为蓝色，C-末端为红色，中间为血红素
鑑定
標誌	PAS
Pfam	PF00989（旧版）
InterPro（英语：InterPro）	IPR013767
SMART（英语：Simple Modular Architecture Research Tool）	PAS
PROSITE（英语：PROSITE）	PDOC50112
SCOP（英语：Structural Classification of Proteins）	2phy / SUPFAM
CDD（英语：Conserved Domain Database）	cd00130
現有可用的蛋白結構：
Pfam	結構（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	結構概要
PDB	1byw, 1d06, 1d7e, 1dp6, 1dp8, 1dp9, 1drm, 1ew0, 1f98, 1f9i, 1gsv, 1gsw, 1gsx, 1kou, 1ll8, 1lsv, 1lsw, 1lsx, 1lt0, 1mzu, 1nwz, 1odv, 1ot6, 1ot9, 1ota, 1otb, 1otd, 1ote, 1oti, 1s1y, 1s1z, 1s4r, 1s4s, 1s66, 1s67, 1t18, 1t19, 1t1a, 1t1b, 1t1c, 1ts0, 1ts6, 1ts7, 1ts8, 1ugu, 1uwn, 1uwp, 1v9y, 1v9z, 1vb6, 1wa9, 1xfn, 1xfq, 1xj2, 1xj3, 1xj4, 1xj6, 1y28, 2d01, 2d02, 2phy, 2pyp, 2pyr, 3phy, 3pyp

PAS结构域（英語：PAS domain）也称为PAS折叠（英語：PAS fold）是一种在细菌、古菌和真核生物中都存在的蛋白质结构域^[2]。其功能为检测小分子物质，如检测氧气的EPAS1等^[3]^[4]^[5]。

参考文献编辑

^ PDB 1y28; Dunham CM, Dioum EM, Tuckerman JR, Gonzalez G, Scott WG, Gilles-Gonzalez MA. A distal arginine in oxygen-sensing heme-PAS domains is essential to ligand binding, signal transduction, and structure. Biochemistry. July 2003, 42 (25): 7701–8 [2023-01-04]. PMID 12820879. doi:10.1021/bi0343370. （原始内容存档于2023-01-20）.
^ Henry, Jonathan T.; Crosson, Sean. Ligand-binding PAS domains in a genomic, cellular, and structural context. Annual Review of Microbiology. 1 January 2011, 65: 261–286. PMC 3298442  . PMID 21663441. doi:10.1146/annurev-micro-121809-151631.
^ Liu, Yu C.; Machuca, Mayra A.; Beckham, Simone A.; Gunzburg, Menachem J.; Roujeinikova, Anna. Structural basis for amino-acid recognition and transmembrane signalling by tandem Per-Arnt-Sim (tandem PAS) chemoreceptor sensory domains. Acta Crystallographica Section D. 1 October 2015, 71 (10): 2127–2136. PMID 26457436. doi:10.1107/S139900471501384X.
^ Möglich, Andreas; Ayers, Rebecca A.; Moffat, Keith. Structure and signaling mechanism of Per-ARNT-Sim domains. Structure. 14 October 2009, 17 (10): 1282–1294. PMC 3092527  . PMID 19836329. doi:10.1016/j.str.2009.08.011.
^ Hennig, Sven; Strauss, Holger M.; Vanselow, Katja; Yildiz, Özkan; Schulze, Sabrina; Arens, Julia; Kramer, Achim; Wolf, Eva. Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2. PLOS Biology. 28 April 2009, 7 (4): e1000094. PMC 2671562  . PMID 19402751. doi:10.1371/journal.pbio.1000094.

[pmid12820879-1] PDB 1y28; Dunham CM, Dioum EM, Tuckerman JR, Gonzalez G, Scott WG, Gilles-Gonzalez MA. A distal arginine in oxygen-sensing heme-PAS domains is essential to ligand binding, signal transduction, and structure. Biochemistry. July 2003, 42 (25): 7701–8 [2023-01-04]. PMID 12820879. doi:10.1021/bi0343370. （原始内容存档于2023-01-20）.

[2] Henry, Jonathan T.; Crosson, Sean. Ligand-binding PAS domains in a genomic, cellular, and structural context. Annual Review of Microbiology. 1 January 2011, 65: 261–286. PMC 3298442  . PMID 21663441. doi:10.1146/annurev-micro-121809-151631.

[3] Liu, Yu C.; Machuca, Mayra A.; Beckham, Simone A.; Gunzburg, Menachem J.; Roujeinikova, Anna. Structural basis for amino-acid recognition and transmembrane signalling by tandem Per-Arnt-Sim (tandem PAS) chemoreceptor sensory domains. Acta Crystallographica Section D. 1 October 2015, 71 (10): 2127–2136. PMID 26457436. doi:10.1107/S139900471501384X.

[4] Möglich, Andreas; Ayers, Rebecca A.; Moffat, Keith. Structure and signaling mechanism of Per-ARNT-Sim domains. Structure. 14 October 2009, 17 (10): 1282–1294. PMC 3092527  . PMID 19836329. doi:10.1016/j.str.2009.08.011.

[katja-5] Hennig, Sven; Strauss, Holger M.; Vanselow, Katja; Yildiz, Özkan; Schulze, Sabrina; Arens, Julia; Kramer, Achim; Wolf, Eva. Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2. PLOS Biology. 28 April 2009, 7 (4): e1000094. PMC 2671562  . PMID 19402751. doi:10.1371/journal.pbio.1000094.

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PAS结构域

参考文献 编辑

参考文献编辑