S-18986
化合物
S-18986，是一种与环噻嗪相关的AMPA受体正变构调节剂。动物研究發現S-18986有促智和神经保护的作用，另外這種物質能誘導大脑海馬體及额叶皮层中脑源性神经营养因子和α-氨基-3-羥基-5-甲基-4-異惡唑丙酸（AMPA）介导去甲肾上腺素及乙酰胆碱释放。[1][2][3][4][5][6][7][8][9][10]
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| CAS号 | 175340-20-2  |
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| CompTox Dashboard (EPA) | |
| 化学信息 | |
| 化学式 | C10H12N2O2S |
| 摩尔质量 | 224.28 g·mol−1 |
| 3D模型（JSmol） | |
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參見 编辑
参考文獻 编辑
- ^ (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices. European Journal of Pharmacology. August 2000, 401 (2): 145–53. PMID 10924919. doi:10.1016/S0014-2999(00)00433-7.
- ^ Effects of S 18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats. European Journal of Pharmacology. August 2000, 401 (2): 205–12. PMID 10924928. doi:10.1016/S0014-2999(00)00429-5.
- ^ Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain. Brain Research. April 2003, 970 (1–2): 221–5. PMID 12706264. doi:10.1016/S0006-8993(03)02357-6.
- ^ S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat. Neuroscience Letters. May 2004, 361 (1–3): 120–3. PMID 15135908. doi:10.1016/j.neulet.2003.12.061.
- ^ Neuropharmacokinetics of a new alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat. Drug Metabolism and Disposition. August 2005, 33 (8): 1137–43. PMID 15860654. doi:10.1124/dmd.105.004424.
- ^ Improvement of episodic contextual memory by S 18986 in middle-aged mice: comparison with donepezil. Psychopharmacology. July 2007, 193 (1): 63–73. PMID 17384936. doi:10.1007/s00213-007-0765-4.
- ^ The AMPA modulator S 18986 improves declarative and working memory performances in aged mice. Behavioural Pharmacology. May 2008, 19 (3): 235–44. PMID 18469541. doi:10.1097/FBP.0b013e3282feb0c1.
- ^ Effects of the AMPA receptor modulator S 18986 on measures of cognition and oxidative stress in aged rats. Psychopharmacology. January 2009, 202 (1–3): 225–35. PMID 18762915. doi:10.1007/s00213-008-1301-x.
- ^ GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986. Cell Death and Differentiation. April 2009, 16 (4): 624–37. PMID 19136940. doi:10.1038/cdd.2008.188.
- ^ The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis. Neuropharmacology. September 2009, 57 (3): 277–86. PMID 19501111. doi:10.1016/j.neuropharm.2009.05.010.