同源框

同源(异形)框(英語:Homeobox),或稱「同源匣」是某些影響動物真菌植物發育的基因所擁有的一段DNA序列,擁有同源框的基因稱作同源异形基因,統稱同源异形基因家族。

Homeodomain
Homeodomain-dna-1ahd.png
The Antennapedia homeodomain protein from Drosophila melanogaster bound to a fragment of DNA.[1] The recognition helix and unstructured N-terminus are bound in the major and minor grooves respectively.
鑑定
標誌同源框结构域(Homeodomain)
PfamPF00046
Pfam宗系CL0123
InterPro英语InterProIPR001356
SMART英语Simple Modular Architecture Research ToolSM00389
PROSITE英语PROSITEPDOC00027
SCOP英语Structural Classification of Proteins1ahd / SUPFAM

這段序列之長度約180個核苷酸,能轉錄出一段蛋白質结构域,稱為同源框结构域。

參考文獻编辑

  1. ^ PDB 1AHD; Billeter M, Qian YQ, Otting G, Müller M, Gehring W, Wüthrich K. Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex. Journal of Molecular Biology. Dec 1993, 234 (4): 1084–93. PMID 7903398. doi:10.1006/jmbi.1993.1661. 

參見编辑