PH结构域
PH结构域（英語：PH domain，全称普列克底物蛋白同源结构域，Pleckstrin homology domain）是一类蛋白质结构域，长约120个氨基酸，存在于涉及细胞内信号传导或作为细胞骨架成分的多种蛋白质中。[1][2][3][4][5][6][7]
 酪氨酸蛋白激酶BTK的PH结构域 | |||||||||
| 鑑定 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 標誌 | PH | ||||||||
| Pfam | PF00169（旧版） | ||||||||
| Pfam宗系 | CL0266（旧版） | ||||||||
| InterPro | IPR001849 | ||||||||
| SMART | PH | ||||||||
| PROSITE | PDOC50003 | ||||||||
| SCOP | 1dyn / SUPFAM | ||||||||
| OPM家族 | 49 | ||||||||
| OPM蛋白 | 1pls | ||||||||
| CDD | cd00821 | ||||||||
| |||||||||
参考文献 编辑
- ^ Mayer BJ, Ren R, Clark KL, Baltimore D. A putative modular domain present in diverse signaling proteins. Cell. May 1993, 73 (4): 629–30. PMID 8500161. S2CID 44282241. doi:10.1016/0092-8674(93)90244-K.
- ^ Haslam RJ, Koide HB, Hemmings BA. Pleckstrin domain homology. Nature. May 1993, 363 (6427): 309–10. PMID 8497315. S2CID 4334376. doi:10.1038/363309b0.
- ^ Musacchio A, Gibson T, Rice P, Thompson J, Saraste M. The PH domain: a common piece in the structural patchwork of signalling proteins. Trends in Biochemical Sciences. September 1993, 18 (9): 343–8. PMID 8236453. doi:10.1016/0968-0004(93)90071-T.
- ^ Gibson TJ, Hyvönen M, Musacchio A, Saraste M, Birney E. PH domain: the first anniversary. Trends in Biochemical Sciences. September 1994, 19 (9): 349–53. PMID 7985225. doi:10.1016/0968-0004(94)90108-2.
- ^ Pawson T. Protein modules and signalling networks. Nature. February 1995, 373 (6515): 573–80. PMID 7531822. S2CID 4324726. doi:10.1038/373573a0.
- ^ Ingley E, Hemmings BA. Pleckstrin homology (PH) domains in signal transduction. Journal of Cellular Biochemistry. December 1994, 56 (4): 436–43. PMID 7890802. doi:10.1002/jcb.240560403.
- ^ Saraste M, Hyvönen M. Pleckstrin homology domains: a fact file. Current Opinion in Structural Biology. June 1995, 5 (3): 403–8. PMID 7583640. doi:10.1016/0959-440X(95)80104-9.
外部链接 编辑
- Nash Lab Protein Interaction Domains - PH domain description[永久失效連結]
- Template:UMichOPM - Calculated orientations of PH domains in membranes