TAS2R43
位於12號人類染色體的基因
味觉感受器，类型2，成员43，TAS2R43 是一个人类基因组中TAS2R43基因编码的蛋白质，是苦味味觉感受器的一员。[1][2]
| 味觉感受器，类型2，成员43 | |||
|---|---|---|---|
| 标识 | |||
| 代号 | TAS2R43; T2R43; T2R52 | ||
| 扩展标识 | 遗传学：612668 同源基因：128798 IUPHAR: GeneCards: TAS2R43 Gene | ||
| 直系同源体 | |||
| 物种 | 人类 | 小鼠 | |
| Entrez | 259289 | n/a | |
| Ensembl | ENSG00000255374 | n/a | |
| UniProt | P59537 | n/a | |
| mRNA序列 | NM_176884 | n/a | |
| 蛋白序列 | NP_795365 | n/a | |
| 基因位置 |
Chr 12: 11.24 – 11.24 Mb | n/a | |
| PubMed查询 | [1] | n/a | |
另见
编辑参考文献
编辑- ^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. Oct 2002, 32 (3): 397–401. PMID 12379855. doi:10.1038/ng1014.
- ^ Entrez Gene: TAS2R43 taste receptor, type 2, member 43.
延伸阅读
编辑- Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction.. J. Biol. Chem. 2002, 277 (1): 1–4. PMID 11696554. doi:10.1074/jbc.R100054200.
- Montmayeur JP, Matsunami H. Receptors for bitter and sweet taste.. Curr. Opin. Neurobiol. 2002, 12 (4): 366–71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
- Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Zhang Y, Hoon MA, Chandrashekar J; et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.. Cell. 2003, 112 (3): 293–301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
- Conte C, Ebeling M, Marcuz A; et al. Identification and characterization of human taste receptor genes belonging to the TAS2R family.. Cytogenet. Genome Res. 2003, 98 (1): 45–53. PMID 12584440. doi:10.1159/000068546.
- Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Fischer A, Gilad Y, Man O, Pääbo S. Evolution of bitter taste receptors in humans and apes.. Mol. Biol. Evol. 2005, 22 (3): 432–6. PMID 15496549. doi:10.1093/molbev/msi027.
- Kuhn C, Bufe B, Winnig M; et al. Bitter taste receptors for saccharin and acesulfame K.. J. Neurosci. 2005, 24 (45): 10260–5. PMID 15537898. doi:10.1523/JNEUROSCI.1225-04.2004.
- Go Y, Satta Y, Takenaka O, Takahata N. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.. Genetics. 2006, 170 (1): 313–26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.
- Behrens M, Bartelt J, Reichling C; et al. Members of RTP and REEP gene families influence functional bitter taste receptor expression.. J. Biol. Chem. 2006, 281 (29): 20650–9. PMID 16720576. doi:10.1074/jbc.M513637200.
