TAS2R50
位於12號人類染色體的基因
味觉感受器，类型2，成员50，TAS2R50 是一个人类基因组中TAS2R50基因编码的蛋白质，是苦味味觉感受器的一员。[1][2][3][4]
| 味觉感受器，类型2，成员50 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 标识 | |||||||||||||
| 代号 | TAS2R50; T2R50; T2R51; TAS2R51 | ||||||||||||
| 扩展标识 | 遗传学：609627 同源基因：88474 IUPHAR: GeneCards: TAS2R50 Gene | ||||||||||||
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| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 259296 | n/a | |||||||||||
| Ensembl | ENSG00000212126 | n/a | |||||||||||
| UniProt | P59544 | n/a | |||||||||||
| mRNA序列 | NM_176890 | n/a | |||||||||||
| 蛋白序列 | NP_795371 | n/a | |||||||||||
| 基因位置 |
Chr 12: 11.14 – 11.14 Mb | n/a | |||||||||||
| PubMed查询 | [1] | n/a | |||||||||||
另见
编辑参考文献
编辑- ^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. Oct 2002, 32 (3): 397–401. PMID 12379855. doi:10.1038/ng1014.
- ^ Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ. Identification and characterization of human taste receptor genes belonging to the TAS2R family. Cytogenet Genome Res. Feb 2003, 98 (1): 45–53. PMID 12584440. doi:10.1159/000068546.
- ^ Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP. Identification of Four Gene Variants Associated with Myocardial Infarction. Am J Hum Genet. Sep 2005, 77 (4): 596–605. PMC 1275608
. PMID 16175505. doi:10.1086/491674.
- ^ Entrez Gene: TAS2R50 taste receptor, type 2, member 50.
进一步阅读
编辑- Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction. J. Biol. Chem. 2002, 277 (1): 1–4. PMID 11696554. doi:10.1074/jbc.R100054200.
- Montmayeur JP, Matsunami H. Receptors for bitter and sweet taste. Curr. Opin. Neurobiol. 2002, 12 (4): 366–71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
- Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Zhang Y; Hoon MA; Chandrashekar J; et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell. 2003, 112 (3): 293–301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
- Gerhard DS; Wagner L; Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Fischer A, Gilad Y, Man O, Pääbo S. Evolution of bitter taste receptors in humans and apes. Mol. Biol. Evol. 2005, 22 (3): 432–6. PMID 15496549. doi:10.1093/molbev/msi027.
- Go Y, Satta Y, Takenaka O, Takahata N. Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates. Genetics. 2006, 170 (1): 313–26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.