TATA结合蛋白

位於6號人類染色體的基因


TATA结合蛋白质(英語:TATA-binding proteinTBP)是一种通用转录因子,具体结合于DNA序列上的TATA盒。TATA盒位于真核基因的转录起始位点上游约30个bp,属于啟動子[5]。TBP可以和各个TBP相关因子共同组成通用转录因子TFIID,再进一步组成RNA聚合酶Ⅱ转录起始复合物[6]

TATA结合蛋白
Protein TBP PDB 1c9b.png
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名TBP;, GTF2D, GTF2D1, HDL4, SCA17, TFIID, TATA-box binding protein, TATA-binding protein
外部IDOMIM600075 MGI101838 HomoloGene2404 GeneCardsTBP
相關疾病
spinocerebellar ataxia type 17[1]
基因位置(人类
6號染色體
染色体6號染色體[2]
6號染色體
TATA结合蛋白的基因位置
TATA结合蛋白的基因位置
基因座6q27起始170,554,302 bp[2]
终止170,572,870 bp[2]
RNA表达模式
PBB GE TBP 203135 at fs.png
查阅更多表达数据
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_003194
NM_001172085

NM_013684

蛋白序列

NP_001165556
NP_003185

NP_038712

基因位置​(UCSC)Chr 6: 170.55 – 170.57 Mb无数据
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠
TBP
PDB 1ngm EBI.jpg
crystal structure of a yeast brf1-tbp-dna ternary complex
鑑定
標誌TBP
PfamPF00352
Pfam宗系CL0407
InterPro英语InterProIPR000814
PROSITE英语PROSITEPDOC00303
 SCOP英语Structural Classification of Proteins1tbp / SUPFAM

蛋白质的相互作用编辑

TATA结合蛋白与下列蛋白質进行互作

参考文献编辑

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外部链接编辑