培妥莫单抗

化合物

培妥莫单抗INN:pemtumomab;商品名:Theragyn),或译潘妥莫单抗,是一种用于治疗癌症的小鼠单克隆抗体。该药物通过多态性上皮黏蛋白(PEM或MUC1)对多种类型的癌症(例如卵巢癌腹膜癌)具有亲和力,并将放射性同位素钇-90输送到肿瘤中。[1]截至2009年,它正在进行III期临床试验。[2]

培妥莫单抗
单克隆抗体
种类?
目标MUC1
临床资料
商品名英语Drug nomenclatureTheragyn
给药途径腹膜给药
ATC码
  • 未分配
识别信息
CAS号646032-04-4  checkY
ChemSpider
  • none

它已在欧洲获得孤儿药地位。[3]

参考资料

编辑
  1. ^ Oei AL, Moreno M, Verheijen RH, Sweep FC, Thomas CM, Massuger LF, von Mensdorff-Pouilly S. Induction of IgG antibodies to MUC1 and survival in patients with epithelial ovarian cancer. International Journal of Cancer. October 2008, 123 (8): 1848–53. PMID 18661524. S2CID 2287723. doi:10.1002/ijc.23725 . 
  2. ^ Clinical trial number NCT00004115 for "Monoclonal Antibody Therapy in Treating Patients With Ovarian Cancer or Primary Peritoneal Cancer in Remission Following Surgery and Chemotherapy" at ClinicalTrials.gov
  3. ^ Antisoma's Lead Product, Pemtumomab Granted European Orphan Drug Status[失效链接]