丙基吡唑三醇

化合物

丙基吡唑三醇PropylpyrazoletriolPPT),是一種合成非甾體ERα激動劑,選擇性是ERβ的400倍[1],常用於研究ERα的功能。[2][3][4]最初科學家認爲PPT對ERα有高度選擇性,唯後來發現PPT也可作GPER(G蛋白偶聯雌激素受體1,GPR30)激動劑[5]

丙基吡唑三醇
識別資訊
  • 4-[2,3-bis(4-hydroxyphenyl)-4-propyl-1H-pyrazol-5-ylidene]cyclohexa-2,5-dien-1-one
CAS號263717-53-9
PubChem CID
ChemSpider
UNII
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C24H22N2O3
摩爾質量386.45 g·mol−1
3D模型(JSmol英語JSmol
  • CCCC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O
  • InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,25,28-29H,2-3H2,1H3
  • Key:UOSWGERPQQOSHS-UHFFFAOYSA-N

參見

編輯

參考文獻

編輯
  1. ^ Ottow, Eckhard; Weinmann, Hilmar. Nuclear Receptors as Drug Targets. John Wiley & Sons. 8 September 2008: 50– [2022-03-23]. ISBN 978-3-527-62330-3. (原始內容存檔於2022-03-23). 
  2. ^ Plant, Tony M.; Zeleznik, Anthony J. Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Academic Press. 15 November 2014: 2311– [2022-03-23]. ISBN 978-0-12-397769-4. (原始內容存檔於2022-03-23). 
  3. ^ Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition. ScholarlyEditions. 26 December 2012: 220– [2022-03-23]. ISBN 978-1-4649-9741-9. (原始內容存檔於2022-05-04). 
  4. ^ Synthesis of Non-steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules (PROTACS).. 2008: 11–. ISBN 978-0-549-90990-3. 
  5. ^ Estrogen biology: new insights into GPER function and clinical opportunities. Molecular and Cellular Endocrinology. May 2014, 389 (1–2): 71–83. PMC 4040308 . PMID 24530924. doi:10.1016/j.mce.2014.02.002.