1-羥基菲

化合物

1-羥基菲(英語:1-Hydroxyphenanthrene)或叫1-羥菲,是一種菲酚的人體代謝物,可以在暴露於多環芳香烴的人的尿液中檢測到。[1]

1-羥基菲
Chemical structure of 1-hydroxyphenanthrene
IUPAC名
Phenanthren-1-ol
菲-1-酚
別名 1-菲酚
1-菲醇
1-羥基菲
1-羥菲
識別
CAS號 2433-56-9  checkY
PubChem 98490
ChemSpider 88945
SMILES
 
  • C1=CC=C2C(=C1)C=CC3=C2C=CC=C3O
性質
化學式 C14H10O
摩爾質量 194.23 g·mol⁻¹
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

它還可以用作海洋魚膽汁中多環芳香烴污染的標記物。[2]

在菲生物降解的情況下,模型真菌雅致小克銀漢霉產生1-羥基菲(菲1-O-β-葡萄糖)的糖苷共軛物。[3]

與吸煙的關係

編輯

對於2-3-4-羥基菲1-羥基芘,發現了與每天吸食的香煙有關的高度顯着差異和劑量反應關係,但對於1-羥基菲則沒有。[4]

參考資料

編輯
  1. ^ PAH metabolites (1-hydroxyphenanthrene, 4-hydroxyphenanthrene, 9-hydroxyphenanthrene, 1-hydroxypyrene). The MAK Collection for Occupational Health and Safety, Biomonitoring Methods, Vol. 6 (article頁面存檔備份,存於網際網路檔案館))
  2. ^ PAH Metabolites in Bile Fluids of Dab (Limanda limanda) and Flounder (Platichthys flesus): Spatial Distribution and Seasonal Changes. Ulrike Kammann, Environmental Science and Pollution Research - International, March 2007, Volume 14, Issue 2, pages 102-108, doi:10.1065/espr2006.05.308
  3. ^ Cerniglia, C. E.; Campbell, W. L.; Freeman, J. P.; Evans, F. E. Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans. Applied and Environmental Microbiology. 1989, 55 (9): 2275–2279. PMC 203068 . PMID 2802607. doi:10.1128/AEM.55.9.2275-2279.1989. 
  4. ^ Urinary monohydroxylated phenanthrenes and hydroxypyrene – the effects of smoking habits and changes induced by smoking on monooxygenase-mediated metabolism. Heudorf U and Angerer J, International Archives of Occupational and Environmental Health, April 2001, Volume 74, Issue 3, pages 177-183, doi:10.1007/s004200000215

外部連結

編輯