Daoy(ATCC編號HTB-186[1])是永生的人類原發性髓母細胞瘤細胞系,最初在1985年分離自一名4歲的白人男性癌症患者小腦[2],經培養的細胞在裸鼠中很容易致瘤,並且迅速生長及易於傳代,其蛋白質組和表型目前已應用於多項研究[3][4][5]。有研究利用DAOY細胞模型,確定蘿蔔硫素英語Sulforaphane成神經管細胞瘤細胞凋亡的新型誘導劑[6]

參考資料

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  1. ^ HTB-186. ATCC. [2019-12-18]. (原始內容存檔於2019-12-18). 
  2. ^ Jacobsen, PF; Jenkyn, DJ; Papadimitriou, JM. Establishment of a human medulloblastoma cell line and its heterotransplantation into nude mice.. Journal of neuropathology and experimental neurology. 1985-09, 44 (5): 472–85 [2019-12-18]. PMID 2993532. doi:10.1097/00005072-198509000-00003. (原始內容存檔於2019-12-18). 
  3. ^ Martelli, C; D'Angelo, L; Barba, M; Baranzini, M; Inserra, I; Iavarone, F; Vincenzoni, F; Tamburrini, G; Massimi, L; Rocco, CD; Caldarelli, M; Messana, I; Michetti, F; Castagnola, M; Lattanzi, W; Desiderio, C. Top-down proteomic characterization of DAOY medulloblastoma tumor cell line.. EuPA open proteomics. 2016-09, 12: 13–21 [2019-12-18]. PMID 29900115. doi:10.1016/j.euprot.2016.03.015. (原始內容存檔於2019-12-18). 
  4. ^ Peyrl, A; Krapfenbauer, K; Slavc, I; Yang, JW; Strobel, T; Lubec, G. Protein profiles of medulloblastoma cell lines DAOY and D283: identification of tumor-related proteins and principles.. Proteomics. 2003-09, 3 (9): 1781–800 [2019-12-18]. PMID 12973738. doi:10.1002/pmic.200300460. (原始內容存檔於2019-12-18). 
  5. ^ Srivastava, VK; Nalbantoglu, J. Flow cytometric characterization of the DAOY medulloblastoma cell line for the cancer stem-like phenotype.. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2008-10, 73 (10): 940–8 [2019-12-18]. PMID 18773455. doi:10.1002/cyto.a.20633. (原始內容存檔於2019-12-18). 
  6. ^ Gingras, D; Gendron, M; Boivin, D; Moghrabi, A; Théorêt, Y; Béliveau, R. Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables.. Cancer letters. 2004-01-08, 203 (1): 35–43 [2019-12-18]. PMID 14670615. doi:10.1016/j.canlet.2003.08.025. (原始內容存檔於2019-12-18). 

外部連結

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