N-苯基哌嗪
化合物
N-苯基哌嗪是一種有機化合物,化學式為C10H14N2。它可由氯苯和哌嗪在叔丁醇鉀的存在下於二氧六環中反應得到,[2]也有文獻以溴苯為原料、氫氧化鈉為鹼進行反應。[3]它的哌嗪環一段的N-H還能繼續發生反應,如和2-氯-6-甲基吡啶在鹼的存在下反應,得到1-(6-甲基吡啶-2-基)-4-苯基哌嗪。[4]
N-苯基哌嗪 | |
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IUPAC名 1-Phenylpiperazine | |
識別 | |
CAS號 | 92-54-6 ![]() |
PubChem | 7096 |
ChemSpider | 6829 |
SMILES |
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性質 | |
化學式 | C10H14N2 |
摩爾質量 | 162.23 g/mol g·mol⁻¹ |
外觀 | 無色至黃色液體 |
密度 | 1.028 g/cm3 |
熔點 | 18.8 °C(292 K) |
沸點 | 287.2 °C(560 K) |
溶解性(水) | 10 g(25 °C)[1] |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
參考文獻
編輯- ^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-04-10]
- ^ Muthukumaran Nirmala, Gandhi Saranya, Periasamy Viswanathamurthi, Roberta Bertani, Paolo Sgarbossa, Jan Grzegorz Malecki. Organonickel complexes encumbering bis-imidazolylidene carbene ligands: Synthesis, X-ray structure and catalytic insights on Buchwald-Hartwig amination reactions. Journal of Organometallic Chemistry. 2017-03, 831: 1–10 [2021-04-10]. doi:10.1016/j.jorganchem.2016.12.029. (原始內容存檔於2020-02-16) (英語).
- ^ Atul Kumar, Ajay Kumar Bishnoi. Application of nanoparticle mediated N-arylation of amines for the synthesis of pharmaceutical entities using vit-E analogues as amphiphiles in water. RSC Advances. 2015, 5 (26): 20516–20520 [2021-04-10]. ISSN 2046-2069. doi:10.1039/C4RA15267K (英語).
- ^ Fei-Dong Huang, Chang Xu, Dong-Dong Lu, Dong-Sheng Shen, Tian Li, Feng-Shou Liu. Pd-PEPPSI-IPent An Promoted Deactivated Amination of Aryl Chlorides with Amines under Aerobic Conditions. The Journal of Organic Chemistry. 2018-08-17, 83 (16): 9144–9155 [2021-04-10]. ISSN 0022-3263. doi:10.1021/acs.joc.8b01205. (原始內容存檔於2021-12-15) (英語).