全氟辛烷磺酸

全氟辛烷磺酸
	系統名; 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-1-octanesulfonic acid
別名	PFOS
識別
CAS號	1763-23-1
PubChem	74483
ChemSpider	67068
SMILES	FC(F)(C(F)(F)S(=O)(=O)O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F;
InChI	1/C8HF17O3S/c9-1(10,3(13,14)5(17,18)7(21,22)23)2(11,12)4(15,16)6(19,20)8(24,25)29(26,27)28/h(H,26,27,28);
InChIKey	YFSUTJLHUFNCNZ-UHFFFAOYAS
EINECS	217-179-8
ChEBI	39421
KEGG	C18142
性質
化學式	C8HF17O3S
摩爾質量	500.13 g/mol g·mol⁻¹
沸點	133 °C（406 K）（6 torr）
pKa	<<0; -3.27±0.50（25 °C）
危險性
警示術語	R：R61, R20/22, R40, R48/25, R64, R51/53
安全術語	S：S53, S45, S61
歐盟分類	Toxic (T); Dangerous for the environment (N)
相關物質
相關化合物	Perfluorooctanoic acid (PFOA), Perfluorobutanesulfonic acid (PFBS), Perfluorooctanesulfonamide (PFOSA), Perfluorononanoic acid (PFNA)
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

全氟辛烷磺酸（英語：Perfluorooctanesulfonic acid，PFOS，共軛酸鹼對為全氟辛烷磺酸根），是一種人造的含氟表面活性劑和環境污染物。全氟辛烷磺酸是3M公司生產的思高潔（英語：Scotchgard）(Scotchgard)等多種去污劑中的關鍵成分。2009年5月，PFOS列入到斯德哥爾摩環境保護國際公約附件B中^[6]。PFOS可以在工業生產中合成，也可以由前體的降解產生。在野生動植物中檢測到的全氟辛烷磺酸水平被認為足以影響健康參數，最近發現全氟辛烷磺酸的血清水平升高與美國普通人群罹患慢性腎臟病的風險增加相關^[7]。「這種相關聯繫獨立於諸如年齡，性別，種族/民族，身高體重指數，糖尿病，高血壓和血清膽固醇水平等混雜因素。」 ^[7]。

它在2023年被列入IARC第2B類致癌物質。^[8]

參考文獻編輯

^ 存档副本. [2020-09-30]. （原始內容存檔於2014-12-13）.
^ "Hazardous Substances Data Bank" data were obtained from the National Library of Medicine (US). Retrieved from SciFinder. [2020-11-19].
^ Cheng J, Psillakis E, Hoffmann MR, Colussi AJ. Acid dissociation versus molecular association of perfluoroalkyl oxoacids: Environmental implications. J. Phys. Chem. A. July 2009, 113 (29): 8152–8156. PMID 19569653. doi:10.1021/jp9051352.
^ Rayne S, Forest K, Friesen KJ. Extending the semi-empirical PM6 method for carbon oxyacid pKa prediction to sulfonic acids: Application towards congener-specific estimates for the environmentally and toxicologically relevant C1 through C8 perfluoroalkyl derivatives. Nature Precedings. 2009. doi:10.1038/npre.2009.3011. hdl:10101/npre.2009.2922.1.
^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2020 ACD/Labs). Retrieved from SciFinder. [2020-11-19].
^ Governments unite to step-up reduction on global DDT reliance and add nine new chemicals under international treaty. Geneva: Stockholm Convention Secretariat. 8 May 2008 [2018-05-23]. （原始內容存檔於2016-04-19）.
^ ^7.0 ^7.1 Shankar, Anoop; Jie Xiao; Alan Ducatman. Perfluoroalkyl Chemicals and Chronic Kidney Disease in US Adults. American Journal of Epidemiology. 2011-10-15, 174 (8): 893–900 [2011-10-10]. PMC 3218627  . PMID 21873601. doi:10.1093/aje/kwr171. （原始內容存檔於2013-03-24）.
^ IARC MONOGRAPHS ON THE IDENTIFICATION OF CARCINOGENIC HAZARDS TO HUMANS. WHO. 2023-12-01 [2023-12-06].

[1] 存档副本. [2020-09-30]. （原始內容存檔於2014-12-13）.

[2] "Hazardous Substances Data Bank" data were obtained from the National Library of Medicine (US). Retrieved from SciFinder. [2020-11-19].

[Cheng2009-3] Cheng J, Psillakis E, Hoffmann MR, Colussi AJ. Acid dissociation versus molecular association of perfluoroalkyl oxoacids: Environmental implications. J. Phys. Chem. A. July 2009, 113 (29): 8152–8156. PMID 19569653. doi:10.1021/jp9051352.

[Rayne2010-4] Rayne S, Forest K, Friesen KJ. Extending the semi-empirical PM6 method for carbon oxyacid pKa prediction to sulfonic acids: Application towards congener-specific estimates for the environmentally and toxicologically relevant C1 through C8 perfluoroalkyl derivatives. Nature Precedings. 2009. doi:10.1038/npre.2009.3011. hdl:10101/npre.2009.2922.1.

[5] Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2020 ACD/Labs). Retrieved from SciFinder. [2020-11-19].

[PR09May-6] Governments unite to step-up reduction on global DDT reliance and add nine new chemicals under international treaty. Geneva: Stockholm Convention Secretariat. 8 May 2008 [2018-05-23]. （原始內容存檔於2016-04-19）.

[Shankar_et_al,_2011-7] 7.0 ^7.1 Shankar, Anoop; Jie Xiao; Alan Ducatman. Perfluoroalkyl Chemicals and Chronic Kidney Disease in US Adults. American Journal of Epidemiology. 2011-10-15, 174 (8): 893–900 [2011-10-10]. PMC 3218627  . PMID 21873601. doi:10.1093/aje/kwr171. （原始內容存檔於2013-03-24）.

[8] IARC MONOGRAPHS ON THE IDENTIFICATION OF CARCINOGENIC HAZARDS TO HUMANS. WHO. 2023-12-01 [2023-12-06].

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全氟辛烷磺酸


系統名 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-1-octanesulfonic acid^[1]
別名	PFOS
識別
CAS號	1763-23-1 ^Y
PubChem	74483
ChemSpider	67068
SMILES	FC(F)(C(F)(F)S(=O)(=O)O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
InChI	1/C8HF17O3S/c9-1(10,3(13,14)5(17,18)7(21,22)23)2(11,12)4(15,16)6(19,20)8(24,25)29(26,27)28/h(H,26,27,28)
InChIKey	YFSUTJLHUFNCNZ-UHFFFAOYAS
EINECS	217-179-8
ChEBI	39421
KEGG	C18142
性質
化學式	C₈HF₁₇O₃S
摩爾質量	500.13 g/mol g·mol⁻¹
沸點	133 °C（406 K）（6 torr）^[2]
pK_a	<<0^[3]^[4] -3.27±0.50（25 °C）^[5]
危險性
警示術語	R：R61, R20/22, R40, R48/25, R64, R51/53
安全術語	S：S53, S45, S61
歐盟分類	Toxic (T) Dangerous for the environment (N)
相關物質
相關化合物	Perfluorooctanoic acid (PFOA), Perfluorobutanesulfonic acid (PFBS), Perfluorooctanesulfonamide (PFOSA), Perfluorononanoic acid (PFNA)
若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

全氟辛烷磺酸

參考文獻 編輯

參考文獻編輯