A-84543
化合物
A-84543是一种含氮有机化合物，分子式C11H16N2O，是美国雅培公司研发的烟碱型乙酰胆碱受体激动剂，能作为开发相关化合物的先导化合物。[1][2][3][4]
 | |
| 识别信息 | |
|---|---|
| |
| CAS号 | 161416-43-9  [NIH] |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| 化学信息 | |
| 化学式 | C11H16N2O |
| 摩尔质量 | 192.26 g·mol−1 |
| 3D模型（JSmol） | |
| |
| |
参考文献
编辑- ^ Abreo MA, Lin NH, Garvey DS, Gunn DE, Hettinger AM, Wasicak JT, et al. Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. Journal of Medicinal Chemistry. February 1996, 39 (4): 817–25. PMID 8632405. doi:10.1021/jm9506884.
- ^ Lin NH, Gunn DE, Li Y, He Y, Bai H, Ryther KB, et al. Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist. Bioorganic & Medicinal Chemistry Letters. February 1998, 8 (3): 249–54. PMID 9871663. doi:10.1016/S0960-894X(98)00019-5.
- ^ Wei ZL, Xiao Y, Yuan H, Baydyuk M, Petukhov PA, Musachio JL, et al. Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. Journal of Medicinal Chemistry. March 2005, 48 (6): 1721–4. PMID 15771418. doi:10.1021/jm0492406.
- ^ Carreras J, Avenoza A, Busto JH, Peregrina JM. Synthesis of azabicyclo[2.2.n]alkane systems as analogues of 3-[1-methyl-2-(S)-pyrrolidinyl- methoxy]pyridine (A-84543). The Journal of Organic Chemistry. April 2007, 72 (8): 3112–5. PMID 17371077. doi:10.1021/jo0700732.