中國VX神經毒劑

化合物

中國VX神經毒劑CVX )是V系列的有機磷神經毒劑,是VX結構異構體,化學式為C11H26NO2PS,它是一種硫代磷酸酯。 [3]杯[4]芳烴四磺酸的衍生物可以對CVX脫毒[4]有機膦酸水解酶也有對其脫毒的研究。[5]

中國VX神經毒劑[1]
IUPAC名
O-Butyl S-[2-(diethylamino)ethyl] methylphosphonothioate
別名 CVX
甲基硫代磷酸-O-丁基-S-[2-(二乙氨基)乙基]酯
識別
CAS號 468712-10-9  checkY
PubChem 559704
ChemSpider 486553
SMILES
 
  • CCCCOP(=O)(C)SCCN(CC)CC
性質
化學式 C11H26NO2PS
摩爾質量 267.37 g·mol−1
沸點 328.3±44.0 °C[2]
溶解性 3.2 g·L−1(25 °C)[2]
pKa 9.45±0.25(25 °C)[2]
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

參見

編輯

參考文獻

編輯
  1. ^ Antonijevic, B.; Stojiljkovic, M. P. Unequal Efficacy of Pyridinium Oximes in Acute Organophosphate Poisoning. Clinical Medicine & Research. 1 March 2007, 5 (1): 71–82. PMC 1855336 . PMID 17456837. doi:10.3121/cmr.2007.701. 
  2. ^ 2.0 2.1 2.2 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-04-23].
  3. ^ Wandhammer, Marielle; Carletti, Eugénie; Van der Schans, Marcel; Gillon, Emilie; Nicolet, Yvain; Masson, Patrick; Goeldner, Maurice; Noort, Daan; Nachon, Florian. Structural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-agents. Journal of Biological Chemistry. 13 May 2011, 286 (19): 16783–16789. PMC 3089521 . PMID 21454498. doi:10.1074/jbc.M110.209569. 
  4. ^ Christian Schneider, Anne Bierwisch, Marianne Koller, Franz Worek, Stefan Kubik. Detoxification of VX and Other V-Type Nerve Agents in Water at 37 °C and pH 7.4 by Substituted Sulfonatocalix[4]arenes. Angewandte Chemie International Edition. 2016-10-04, 55 (41): 12668–12672 [2021-04-23]. PMC 5113771 . PMID 27627873. doi:10.1002/anie.201606881 (英語). 
  5. ^ Marie Trovaslet-Leroy, Lucie Musilova, Frédérique Renault, Xavier Brazzolotto, Jan Misik, Ladislav Novotny, Marie-Thérèse Froment, Emilie Gillon, Mélanie Loiodice, Laurent Verdier, Patrick Masson, Daniel Rochu, Daniel Jun, Florian Nachon. Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents. Toxicology Letters. 2011-09, 206 (1): 14–23 [2021-04-23]. doi:10.1016/j.toxlet.2011.05.1041. (原始內容存檔於2018-06-17) (英語).