震顫素

震顫素
臨床資料
ATC碼	未分配;
識別資訊
	IUPAC命名法 1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidine; ;
CAS號	51-73-0
PubChem CID	5534;
ChemSpider	5333;
UNII	U817VZ1URQ;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID00199004 ;
化學資訊
化學式	C12H20N2
摩爾質量	192.31 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES C2CCCN2CC#CCN1CCCC1;
	InChI InChI=1S/C12H20N2/c1-2-8-13(7-1)11-5-6-12-14-9-3-4-10-14/h1-4,7-12H2; Key:JSUAJTLKVREZHV-UHFFFAOYSA-N;

震顫素（英語：Tremorine）是一種在科學研究中使動物產生震顫的藥物。這種物質被用於開發治療帕金森病的藥物，因為震顫是帕金森病的主要症狀之一。^[1]^[2]^[3]^[4]^[5]β受體阻滯劑也能有效抵消震顫素的影響。^[6]

震顫素是由埃弗里特等人於1956—57年首先報道的。^[7]^[8]^[9]^[10]

參見

氧代震顫素

參考資料

^ Trautner EM, Gershon S. Use of tremorine for screening anti-parkinsonian drugs. Nature. May 1959, 183 (4673): 1462–3. Bibcode:1959Natur.183.1462T. PMID 13657170. S2CID 4173699. doi:10.1038/1831462a0.
^ Friedman AH, Aylesworth RJ, Friedman G. Tremorine: Its Effect on Amines of the Central Nervous System. Science. September 1963, 141 (3586): 1188–90. Bibcode:1963Sci...141.1188F. PMID 14043364. S2CID 37472968. doi:10.1126/science.141.3586.1188.
^ Menon M, Clark WG, Aures D. Effect of tremorine, oxotremorine and decaborane on brain histamine levels in rats. Pharmacological Research Communications. 1971, 3 (4): 345–350. doi:10.1016/0031-6989(71)90005-1.
^ Shinozaki H, Hirate K, Ishida M. Further studies on quantification of drug-induced tremor in mice: effects of antitremorgenic agents on tremor frequency. Experimental Neurology. May 1985, 88 (2): 303–15. PMID 3987859. S2CID 7607662. doi:10.1016/0014-4886(85)90193-1.
^ Morais LC, Quintans-Júnior LJ, Franco CI, Almeida JR, Almeida RN. Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology. Pharmacology, Biochemistry, and Behavior. December 2004, 79 (4): 745–9. PMID 15582683. S2CID 28371865. doi:10.1016/j.pbb.2004.10.004.
^ Paul V. The role of adrenergic mechanism in tremorine-induced tremors in rats: antitremor effect of beta-adrenoceptor antagonists. Indian Journal of Physiology and Pharmacology. 1986, 30 (4): 307–12. PMID 2883120.
^ Everett, Guy M. (1956). "Tremor produced by drugs". Nature v. 177(4522), p. 1238. ("In the routine screening of drugs in mice, we have found only ten out of ten thousand compounds which produce sustained tremor. One of these, 1-4 dipyrrolidino-2-butyne, 'Tremorine', in doses of 5–20 mgm./kgm. produces tremor, salivation, meiosis, etc."
^ Everett G.M., Blockus L.E. and Sheppard I.M. (1956). "Tremor induced by tremorine and its antagonism by anti-Parkinson drugs." Science v. 124, p.79.
^ Everett G.M., Blockus L.E., Sheppard I.M. and Toman J.E.P. (1956), Federation Proceedings v. 15, p. 420.
^ Blockus, L. E. and Everett, G. M. (January 1957). "Tremor producing drug 1,4 di-pyrrolidino-2-butyne (Tremorine)", Federation Proceedings v. 16(1), p. 283.

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[1] Trautner EM, Gershon S. Use of tremorine for screening anti-parkinsonian drugs. Nature. May 1959, 183 (4673): 1462–3. Bibcode:1959Natur.183.1462T. PMID 13657170. S2CID 4173699. doi:10.1038/1831462a0.

[2] Friedman AH, Aylesworth RJ, Friedman G. Tremorine: Its Effect on Amines of the Central Nervous System. Science. September 1963, 141 (3586): 1188–90. Bibcode:1963Sci...141.1188F. PMID 14043364. S2CID 37472968. doi:10.1126/science.141.3586.1188.

[3] Menon M, Clark WG, Aures D. Effect of tremorine, oxotremorine and decaborane on brain histamine levels in rats. Pharmacological Research Communications. 1971, 3 (4): 345–350. doi:10.1016/0031-6989(71)90005-1.

[4] Shinozaki H, Hirate K, Ishida M. Further studies on quantification of drug-induced tremor in mice: effects of antitremorgenic agents on tremor frequency. Experimental Neurology. May 1985, 88 (2): 303–15. PMID 3987859. S2CID 7607662. doi:10.1016/0014-4886(85)90193-1.

[5] Morais LC, Quintans-Júnior LJ, Franco CI, Almeida JR, Almeida RN. Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology. Pharmacology, Biochemistry, and Behavior. December 2004, 79 (4): 745–9. PMID 15582683. S2CID 28371865. doi:10.1016/j.pbb.2004.10.004.

[6] Paul V. The role of adrenergic mechanism in tremorine-induced tremors in rats: antitremor effect of beta-adrenoceptor antagonists. Indian Journal of Physiology and Pharmacology. 1986, 30 (4): 307–12. PMID 2883120.

[7] Everett, Guy M. (1956). "Tremor produced by drugs". Nature v. 177(4522), p. 1238. ("In the routine screening of drugs in mice, we have found only ten out of ten thousand compounds which produce sustained tremor. One of these, 1-4 dipyrrolidino-2-butyne, 'Tremorine', in doses of 5–20 mgm./kgm. produces tremor, salivation, meiosis, etc."

[8] Everett G.M., Blockus L.E. and Sheppard I.M. (1956). "Tremor induced by tremorine and its antagonism by anti-Parkinson drugs." Science v. 124, p.79.

[9] Everett G.M., Blockus L.E., Sheppard I.M. and Toman J.E.P. (1956), Federation Proceedings v. 15, p. 420.

[10] Blockus, L. E. and Everett, G. M. (January 1957). "Tremor producing drug 1,4 di-pyrrolidino-2-butyne (Tremorine)", Federation Proceedings v. 16(1), p. 283.

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臨床資料

ATC碼	未分配
識別資訊
IUPAC命名法 1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidine
CAS號	51-73-0
PubChem CID	5534
ChemSpider	5333
UNII	U817VZ1URQ
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID00199004
化學資訊
化學式	C₁₂H₂₀N₂
摩爾質量	192.31 g·mol⁻¹
3D模型（JSmol（英語：JSmol））	交互式圖像
SMILES C2CCCN2CC#CCN1CCCC1
InChI InChI=1S/C12H20N2/c1-2-8-13(7-1)11-5-6-12-14-9-3-4-10-14/h1-4,7-12H2 Key:JSUAJTLKVREZHV-UHFFFAOYSA-N